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• W2086366928 startingPage "397" @default.
• W2086366928 abstract "Acrylamide (ACR) is a chemical used in many industries around the world and more recently was found to form naturally in foods cooked at high temperatures. Acrylamide was shown to be a neurotoxicant, reproductive toxicant, and carcinogen in animal species. Only the neurotoxic effects were observed in humans and only at high levels of exposure in occupational settings. The mechanism underlying neurotoxic effects of ACR may be basic to the other toxic effects seen in animals. This mechanism involves interference with the kinesin-related motor proteins in nerve cells or with fusion proteins in the formation of vesicles at the nerve terminus and eventual cell death. Neurotoxicity and resulting behavioral changes can affect reproductive performance of ACR-exposed laboratory animals with resulting decreased reproductive performance. Further, the kinesin motor proteins are important in sperm motility, which could alter reproduction parameters. Effects on kinesin proteins could also explain some of the genotoxic effects on ACR. These proteins form the spindle fibers in the nucleus that function in the separation of chromosomes during cell division. This could explain the clastogenic effects of the chemical noted in a number of tests for genotoxicity and assays for germ cell damage. Other mechanisms underlying ACR-induced carcinogenesis or nerve toxicity are likely related to an affinity for sulfhydryl groups on proteins. Binding of the sulfhydryl groups could inactive proteins/enzymes involved in DNA repair and other critical cell functions. Direct interaction with DNA may or may not be a major mechanism for cancer induction in animals. The DNA adducts that form do not correlate with tumor sites and ACR is mostly negative in gene mutation assays except at high doses that may not be achievable in the diet. All epidemiologic studies fail to show any increased risk of cancer from either high-level occupational exposure or the low levels found in the diet. In fact, two of the epidemiologic studies show a decrease in cancer of the large bowel. A number of risk assessment studies were performed to estimate increased cancer risk. The results of these studies are highly variable depending on the model. There is universal consensus among international food safety groups in all countries that examined the issue of ACR in the diet that not enough information is available at this time to make informed decisions on which to base any regulatory action. Too little is known about levels of this chemical in different foods and the potential risk from dietary exposure. Avoidance of foods containing ACR would result in worse health issues from an unbalanced diet or pathogens from under cooked foods. There is some consensus that low levels of ACR in the diet are not a concern for neurotoxicity or reproductive toxicity in humans, although further research is need to study the long-term, low-level cumulative effects on the nervous system. Any relationship to cancer risk from dietary exposure is hypothetical at this point and awaits more definitive studies." @default.
• W2086366928 created "2016-06-24" @default.
• W2086366928 creator A5011815738 @default.
• W2086366928 date "2006-12-01" @default.
• W2086366928 modified "2023-10-17" @default.
• W2086366928 title "A Review of the Toxicology of Acrylamide" @default.
• W2086366928 cites W1517337380 @default.
• W2086366928 cites W1587657559 @default.
• W2086366928 cites W1964188139 @default.
• W2086366928 cites W1969513062 @default.
• W2086366928 cites W1972228801 @default.
• W2086366928 cites W1974600347 @default.
• W2086366928 cites W1975973052 @default.
• W2086366928 cites W1976479014 @default.
• W2086366928 cites W1977576128 @default.
• W2086366928 cites W1978270283 @default.
• W2086366928 cites W1995297902 @default.
• W2086366928 cites W1996031053 @default.
• W2086366928 cites W2000833619 @default.
• W2086366928 cites W2001624628 @default.
• W2086366928 cites W2002301313 @default.
• W2086366928 cites W2003718947 @default.
• W2086366928 cites W2004859374 @default.
• W2086366928 cites W2005373772 @default.
• W2086366928 cites W2005573549 @default.
• W2086366928 cites W2005593990 @default.
• W2086366928 cites W2005740946 @default.
• W2086366928 cites W2006017051 @default.
• W2086366928 cites W2007483551 @default.
• W2086366928 cites W2007531409 @default.
• W2086366928 cites W2007694861 @default.
• W2086366928 cites W2013073379 @default.
• W2086366928 cites W2013163371 @default.
• W2086366928 cites W2014968991 @default.
• W2086366928 cites W2019668373 @default.
• W2086366928 cites W2020333543 @default.
• W2086366928 cites W2023309034 @default.
• W2086366928 cites W2024189039 @default.
• W2086366928 cites W2024661178 @default.
• W2086366928 cites W2024805816 @default.
• W2086366928 cites W2027298851 @default.
• W2086366928 cites W2029052623 @default.
• W2086366928 cites W2033264050 @default.
• W2086366928 cites W2035245129 @default.
• W2086366928 cites W2035692542 @default.
• W2086366928 cites W2037523584 @default.
• W2086366928 cites W2037582879 @default.
• W2086366928 cites W2038423344 @default.
• W2086366928 cites W2038870324 @default.
• W2086366928 cites W2039153047 @default.
• W2086366928 cites W2039925106 @default.
• W2086366928 cites W2043637881 @default.
• W2086366928 cites W2044273377 @default.
• W2086366928 cites W2045352871 @default.
• W2086366928 cites W2045879793 @default.
• W2086366928 cites W2047517385 @default.
• W2086366928 cites W2049359937 @default.
• W2086366928 cites W2049563606 @default.
• W2086366928 cites W2049908422 @default.
• W2086366928 cites W2054689776 @default.
• W2086366928 cites W2056539293 @default.
• W2086366928 cites W2057215289 @default.
• W2086366928 cites W2057474661 @default.
• W2086366928 cites W2057599872 @default.
• W2086366928 cites W2059961366 @default.
• W2086366928 cites W2063935922 @default.
• W2086366928 cites W2066780823 @default.
• W2086366928 cites W2071247902 @default.
• W2086366928 cites W2072061005 @default.
• W2086366928 cites W2080317818 @default.
• W2086366928 cites W2081105449 @default.
• W2086366928 cites W2082007696 @default.
• W2086366928 cites W2082842655 @default.
• W2086366928 cites W2085663829 @default.
• W2086366928 cites W2085840338 @default.
• W2086366928 cites W2093951125 @default.
• W2086366928 cites W2094166158 @default.
• W2086366928 cites W2094634820 @default.
• W2086366928 cites W2095377398 @default.
• W2086366928 cites W2097377305 @default.
• W2086366928 cites W2108433727 @default.
• W2086366928 cites W2118172950 @default.
• W2086366928 cites W2124567510 @default.
• W2086366928 cites W2142491963 @default.
• W2086366928 cites W2143070742 @default.
• W2086366928 cites W2146346825 @default.
• W2086366928 cites W2146980306 @default.
• W2086366928 cites W2147713889 @default.
• W2086366928 cites W2149845189 @default.
• W2086366928 cites W2150675704 @default.
• W2086366928 cites W2168893957 @default.
• W2086366928 cites W2169430114 @default.
• W2086366928 cites W2274171631 @default.
• W2086366928 cites W2407064831 @default.
• W2086366928 cites W4247610633 @default.
• W2086366928 doi "https://doi.org/10.1080/10937400600681430" @default.
• W2086366928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17492525" @default.
• W2086366928 hasPublicationYear "2006" @default.

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