FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086366979> ?p ?o ?g. }

• W2086366979 endingPage "1290" @default.
• W2086366979 startingPage "1283" @default.
• W2086366979 abstract "The asialoglycoprotein (ASGP) receptor is an abundant hepatocyte-specific receptor involved in receptor-mediated endocytosis. This receptor's abundance and function is decreased by chronic ethanol administration prior to the appearance of pathology such as necrosis or inflammation. Hence, this study aimed to determine if ASGP receptor function is required to protect against liver injury by utilizing a knockout mouse model lacking functional ASGP receptor in the setting of carbon tetrachloride (CCl(4)) hepatotoxicity. Briefly, ASGP receptor-deficient (RD) mice and wild-type (WT) mice were injected with 1ml/kg body weight of CCl(4). In the subsequent week, mice were monitored for liver damage and pathology (aspartate transaminase (AST), alanine transaminase (ALT) and light microscopy). The consequences of CCl(4) injection were examined by measuring alpha-smooth muscle actin (alpha-SMA) deposition, contents of malondialdehyde and the percentage of apoptotic hepatocytes. After CCl(4) injection, RD mice showed increased liver pathology together with significantly increased activities of AST and ALT compared to that in WT mice. There were also significantly more apoptotic bodies, lipid peroxidation and deposition of alpha-SMA in RD mice versus WT mice following CCl(4) injection. Since these two mouse strains only differ in whether or not they have the ASGP receptor, it can be concluded that proper ASGP receptor function exerted a protective effect against CCl(4) toxicity. Thus, receptor-mediated endocytosis by the ASGP receptor could represent a novel molecular mechanism that is responsible for subsequent liver health or injury." @default.
• W2086366979 created "2016-06-24" @default.
• W2086366979 creator A5006295410 @default.
• W2086366979 creator A5019807060 @default.
• W2086366979 creator A5022129146 @default.
• W2086366979 creator A5048320637 @default.
• W2086366979 creator A5054848607 @default.
• W2086366979 creator A5071942713 @default.
• W2086366979 creator A5090217037 @default.
• W2086366979 date "2009-04-01" @default.
• W2086366979 modified "2023-10-10" @default.
• W2086366979 title "Carbon tetrachloride-induced liver damage in asialoglycoprotein receptor-deficient mice" @default.
• W2086366979 cites W1483729606 @default.
• W2086366979 cites W1602330165 @default.
• W2086366979 cites W1839631757 @default.
• W2086366979 cites W1968442371 @default.
• W2086366979 cites W1978481215 @default.
• W2086366979 cites W1981007299 @default.
• W2086366979 cites W1991921662 @default.
• W2086366979 cites W2006493954 @default.
• W2086366979 cites W2008450208 @default.
• W2086366979 cites W2014168235 @default.
• W2086366979 cites W2016085979 @default.
• W2086366979 cites W2017886654 @default.
• W2086366979 cites W2018251493 @default.
• W2086366979 cites W2020124064 @default.
• W2086366979 cites W2037114323 @default.
• W2086366979 cites W2038305424 @default.
• W2086366979 cites W2048934370 @default.
• W2086366979 cites W2049173074 @default.
• W2086366979 cites W2053054955 @default.
• W2086366979 cites W2059467661 @default.
• W2086366979 cites W2068358820 @default.
• W2086366979 cites W2068762746 @default.
• W2086366979 cites W2074060016 @default.
• W2086366979 cites W2091440199 @default.
• W2086366979 cites W2095328507 @default.
• W2086366979 cites W2098979202 @default.
• W2086366979 cites W2099085608 @default.
• W2086366979 cites W2100837269 @default.
• W2086366979 cites W2116342732 @default.
• W2086366979 cites W2128237788 @default.
• W2086366979 cites W2135047848 @default.
• W2086366979 cites W2136588687 @default.
• W2086366979 cites W2138466097 @default.
• W2086366979 cites W2140675859 @default.
• W2086366979 cites W2175128997 @default.
• W2086366979 cites W2321700180 @default.
• W2086366979 cites W2404318439 @default.
• W2086366979 cites W2412895678 @default.
• W2086366979 cites W82180823 @default.
• W2086366979 doi "https://doi.org/10.1016/j.bcp.2008.12.023" @default.
• W2086366979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2676723" @default.
• W2086366979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19185565" @default.
• W2086366979 hasPublicationYear "2009" @default.
• W2086366979 type Work @default.
• W2086366979 sameAs 2086366979 @default.
• W2086366979 citedByCount "26" @default.
• W2086366979 countsByYear W20863669792012 @default.
• W2086366979 countsByYear W20863669792013 @default.
• W2086366979 countsByYear W20863669792014 @default.
• W2086366979 countsByYear W20863669792015 @default.
• W2086366979 countsByYear W20863669792016 @default.
• W2086366979 countsByYear W20863669792017 @default.
• W2086366979 countsByYear W20863669792018 @default.
• W2086366979 countsByYear W20863669792020 @default.
• W2086366979 countsByYear W20863669792021 @default.
• W2086366979 countsByYear W20863669792022 @default.
• W2086366979 crossrefType "journal-article" @default.
• W2086366979 hasAuthorship W2086366979A5006295410 @default.
• W2086366979 hasAuthorship W2086366979A5019807060 @default.
• W2086366979 hasAuthorship W2086366979A5022129146 @default.
• W2086366979 hasAuthorship W2086366979A5048320637 @default.
• W2086366979 hasAuthorship W2086366979A5054848607 @default.
• W2086366979 hasAuthorship W2086366979A5071942713 @default.
• W2086366979 hasAuthorship W2086366979A5090217037 @default.
• W2086366979 hasBestOaLocation W20863669792 @default.
• W2086366979 hasConcept C11569505 @default.
• W2086366979 hasConcept C126322002 @default.
• W2086366979 hasConcept C134018914 @default.
• W2086366979 hasConcept C160160445 @default.
• W2086366979 hasConcept C170493617 @default.
• W2086366979 hasConcept C181199279 @default.
• W2086366979 hasConcept C185592680 @default.
• W2086366979 hasConcept C202751555 @default.
• W2086366979 hasConcept C2776200302 @default.
• W2086366979 hasConcept C2776637226 @default.
• W2086366979 hasConcept C2778606649 @default.
• W2086366979 hasConcept C2779679107 @default.
• W2086366979 hasConcept C55493867 @default.
• W2086366979 hasConcept C71924100 @default.
• W2086366979 hasConcept C86803240 @default.
• W2086366979 hasConceptScore W2086366979C11569505 @default.
• W2086366979 hasConceptScore W2086366979C126322002 @default.
• W2086366979 hasConceptScore W2086366979C134018914 @default.
• W2086366979 hasConceptScore W2086366979C160160445 @default.
• W2086366979 hasConceptScore W2086366979C170493617 @default.
• W2086366979 hasConceptScore W2086366979C181199279 @default.

• next