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• W2086376699 abstract "Oroxylin A (5,7-dihydroxy-6-methoxyfavone) is a flavonoid compound originated from the root of Scutellaria baicalensis Georgi. Our previous reports suggested that oroxylin A improves memory function in rat, at least in part, by its antagonistic effects on GABAA receptor. In addition, oroxylin A protects neurons from ischemic damage by mechanisms currently not clear. In this study we determined whether oroxylin A modulates the level of brain derived neurotrophic factor (BDNF) in primary rat cortical neuronal culture, which is well known for its role on neuronal survival, neurogenesis, differentiation of neurons and synapses and learning and memory. Treatment of oroxylin A for 3–48 h increased BDNF expression which was analyzed by ELISA assay and Western blot analysis. Oroxylin A induced slow but sustained increases in intracellular calcium level and activated ERK1/2 mitogen activated protein kinase (MAPK). In addition, oroxylin A phosphorylated cyclic AMP response element binding protein (CREB) at Ser 133 in concentration and time dependent manner. Pretreatment with the MAPK inhibitor PD98059 (10 μM) attenuated phosphorylation of ERK1/2 and CREB as well as BDNF production, which suggests that oroxylin A regulates BDNF production by activating MAPK–CREB pathway. GABAA antagonist bicuculline mimicked the effects of oroxylin A on BDNF production as well as MAPK–CREB pathway. Increase in intracellular Ca2+ concentration, phosphorylation of ERK1/2 and CREB, and BDNF expression by oroxylin A was blocked by NMDA receptor inhibitor MK-801 (10 μM) as well as tetrodotoxin (TTX, 0.5 and 1 μM). The results from the present study suggest that the calcium and p-CREB dependent induction of BDNF expression, possibly via activation of synaptic NMDA receptor through the blockade of GABAA activity in cortical neuronal circuitry, might be responsible for the neuroprotective or memory enhancing effects of oroxylin A." @default.
• W2086376699 created "2016-06-24" @default.
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• W2086376699 date "2011-03-01" @default.
• W2086376699 modified "2023-10-06" @default.
• W2086376699 title "Oroxylin A increases BDNF production by activation of MAPK–CREB pathway in rat primary cortical neuronal culture" @default.
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• W2086376699 cites W1966785609 @default.
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• W2086376699 cites W1992529363 @default.
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• W2086376699 cites W2031739172 @default.
• W2086376699 cites W2032596004 @default.
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• W2086376699 cites W2035082265 @default.
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• W2086376699 cites W2064882592 @default.
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• W2086376699 cites W2073677430 @default.
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• W2086376699 cites W2080428182 @default.
• W2086376699 cites W2081070804 @default.
• W2086376699 cites W2081704409 @default.
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• W2086376699 cites W2168007569 @default.
• W2086376699 cites W2170044387 @default.
• W2086376699 cites W2924346946 @default.
• W2086376699 cites W4230454755 @default.
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• W2086376699 doi "https://doi.org/10.1016/j.neures.2010.11.008" @default.
• W2086376699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21145362" @default.
• W2086376699 hasPublicationYear "2011" @default.
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