FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086398187> ?p ?o ?g. }

• W2086398187 endingPage "6987" @default.
• W2086398187 startingPage "6987" @default.
• W2086398187 abstract "To investigate whether trehalose inhibits VEGF-stimulated or inflammatory angiogenesis and the proliferation of myofibroblasts.Normal human dermal fibroblasts and human umbilical vein endothelial cells (HUVECs)were cocultured in trehalose-containing medium (2.5/5.0/7.5/10.0%) with or without VEGF (10 ng/mL). After 11 days, the area, length, joint, and path of neovascularization were evaluated. The effect of topical trehalose on corneal neovascularization was examined in vivo by treating Balb/c mice with alkali burn-induced corneal neovascularization. After 14 days of trehalose treatment, corneal vessels were visualized in flatmounts. The expressions of VEGFR2, phospho-VEGFR2, and vimentin were observed. Then a separate coculture model of the myofibroblasts and HUVECs was used to observe the morphologic changes of the myofibroblasts by trehalose. Furthermore, myofibroblasts were cultured with trehalose to examine the cytokeratin and E-cadherin expressions.In the in vitro models, there was a significant trehalose dose-dependent inhibition of neovascularization. In the in vivo alkali burn models, corneal neovascularization was significantly inhibited by treatments using ≥ 2.5% trehalose eyedrops. The expressions of VEGFR2, phospho-VEGFR2, and vimentin were downregulated by trehalose. When trehalose was added to the medium, the myofibroblasts were transformed into epithelial cell-like cells. The transformed myofibroblasts expressed cytokeratin but not E-cadherin.Trehalose prevents angiogenesis by partially downregulating VEGFR2 expression. In addition, trehalose inhibits the proliferation of myofibroblasts partially by inducing mesenchymal-epithelial transition. These findings suggest that trehalose has potential for use as a new agent that can control angiogenesis and fibrosis and potential for use in glaucoma surgery." @default.
• W2086398187 created "2016-06-24" @default.
• W2086398187 creator A5022863382 @default.
• W2086398187 creator A5045508721 @default.
• W2086398187 creator A5078188464 @default.
• W2086398187 date "2011-08-31" @default.
• W2086398187 modified "2023-09-23" @default.
• W2086398187 title "Effects of Trehalose on VEGF-Stimulated Angiogenesis and Myofibroblast Proliferation: Implications for Glaucoma Filtration Surgery" @default.
• W2086398187 cites W123239899 @default.
• W2086398187 cites W1571263028 @default.
• W2086398187 cites W1987087672 @default.
• W2086398187 cites W1990498907 @default.
• W2086398187 cites W1997844211 @default.
• W2086398187 cites W2004845166 @default.
• W2086398187 cites W2011754264 @default.
• W2086398187 cites W2019161113 @default.
• W2086398187 cites W2026529072 @default.
• W2086398187 cites W2034282738 @default.
• W2086398187 cites W2035162736 @default.
• W2086398187 cites W2037623038 @default.
• W2086398187 cites W2038818854 @default.
• W2086398187 cites W2047328059 @default.
• W2086398187 cites W2054821140 @default.
• W2086398187 cites W2064972529 @default.
• W2086398187 cites W2072732223 @default.
• W2086398187 cites W2110938993 @default.
• W2086398187 cites W2112911107 @default.
• W2086398187 cites W2142851639 @default.
• W2086398187 cites W2154459059 @default.
• W2086398187 cites W2346989971 @default.
• W2086398187 doi "https://doi.org/10.1167/iovs.11-7478" @default.
• W2086398187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21778273" @default.
• W2086398187 hasPublicationYear "2011" @default.
• W2086398187 type Work @default.
• W2086398187 sameAs 2086398187 @default.
• W2086398187 citedByCount "17" @default.
• W2086398187 countsByYear W20863981872012 @default.
• W2086398187 countsByYear W20863981872013 @default.
• W2086398187 countsByYear W20863981872014 @default.
• W2086398187 countsByYear W20863981872015 @default.
• W2086398187 countsByYear W20863981872017 @default.
• W2086398187 countsByYear W20863981872018 @default.
• W2086398187 countsByYear W20863981872019 @default.
• W2086398187 countsByYear W20863981872020 @default.
• W2086398187 countsByYear W20863981872021 @default.
• W2086398187 countsByYear W20863981872022 @default.
• W2086398187 countsByYear W20863981872023 @default.
• W2086398187 crossrefType "journal-article" @default.
• W2086398187 hasAuthorship W2086398187A5022863382 @default.
• W2086398187 hasAuthorship W2086398187A5045508721 @default.
• W2086398187 hasAuthorship W2086398187A5078188464 @default.
• W2086398187 hasConcept C142724271 @default.
• W2086398187 hasConcept C147447768 @default.
• W2086398187 hasConcept C153911025 @default.
• W2086398187 hasConcept C185592680 @default.
• W2086398187 hasConcept C203014093 @default.
• W2086398187 hasConcept C204232928 @default.
• W2086398187 hasConcept C207865475 @default.
• W2086398187 hasConcept C2777844972 @default.
• W2086398187 hasConcept C2778271429 @default.
• W2086398187 hasConcept C2778452849 @default.
• W2086398187 hasConcept C2780394083 @default.
• W2086398187 hasConcept C2780559512 @default.
• W2086398187 hasConcept C502942594 @default.
• W2086398187 hasConcept C55493867 @default.
• W2086398187 hasConcept C71924100 @default.
• W2086398187 hasConcept C86803240 @default.
• W2086398187 hasConcept C95444343 @default.
• W2086398187 hasConceptScore W2086398187C142724271 @default.
• W2086398187 hasConceptScore W2086398187C147447768 @default.
• W2086398187 hasConceptScore W2086398187C153911025 @default.
• W2086398187 hasConceptScore W2086398187C185592680 @default.
• W2086398187 hasConceptScore W2086398187C203014093 @default.
• W2086398187 hasConceptScore W2086398187C204232928 @default.
• W2086398187 hasConceptScore W2086398187C207865475 @default.
• W2086398187 hasConceptScore W2086398187C2777844972 @default.
• W2086398187 hasConceptScore W2086398187C2778271429 @default.
• W2086398187 hasConceptScore W2086398187C2778452849 @default.
• W2086398187 hasConceptScore W2086398187C2780394083 @default.
• W2086398187 hasConceptScore W2086398187C2780559512 @default.
• W2086398187 hasConceptScore W2086398187C502942594 @default.
• W2086398187 hasConceptScore W2086398187C55493867 @default.
• W2086398187 hasConceptScore W2086398187C71924100 @default.
• W2086398187 hasConceptScore W2086398187C86803240 @default.
• W2086398187 hasConceptScore W2086398187C95444343 @default.
• W2086398187 hasIssue "9" @default.
• W2086398187 hasLocation W20863981871 @default.
• W2086398187 hasLocation W20863981872 @default.
• W2086398187 hasOpenAccess W2086398187 @default.
• W2086398187 hasPrimaryLocation W20863981871 @default.
• W2086398187 hasRelatedWork W141893560 @default.
• W2086398187 hasRelatedWork W1597434638 @default.
• W2086398187 hasRelatedWork W2065447656 @default.
• W2086398187 hasRelatedWork W2070613014 @default.
• W2086398187 hasRelatedWork W2086398187 @default.
• W2086398187 hasRelatedWork W2111821015 @default.
• W2086398187 hasRelatedWork W2351152434 @default.
• W2086398187 hasRelatedWork W2398751058 @default.

• next