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- W2086403925 abstract "The immunosuppressive effects of the sedative drug thalidomide have been utilised in a variety of immune disorders. In the present study, 6 patients were treated who developed graft- versus-host disease (GvHD) following allogeneic bone marrow transplantation (BMT) with thalidomide and in a dose range of 200–600 mg daily. Two of 3 patients with chronic GvHD showed clear improvement, whereas none of the 3 patients with acute GvHD derived unequivocal benefit. Although based on a small number of patients, these data suggest that thalidomide may find a useful place in the therapy of GvHD, perhaps specifically in the chronic form of this disorder. thalidomide/graft-versus-host disease/bone marrow transplantationmodels La thalidomide en traitement de la maladie du greffon contre l'hôte (GVH) à la suite d'une transplantation allogénique de moelle osseuse. Les effets immunosuppresseurs de la thalidomide. médicament sédatif, cnt été utilisés dans un but thérapeutique au cours de divers troubles immunitaires. Les auteurs ont traités six malades qui développaient une maladie du greffon contre l'hôte (GVH) à la suite d'une transplantation allogénique de moelle osseuse (BMT) par la thalidomide à des doses allant de 200 à 600 mg par jour. Sur trois des malades qui étaient atteints d'une GVH chronique, deux ont montré une améolioration nette alors qu'aucun des trois malades atteints d'une GVH aigüe n 'a tiré un bénéfice vraiment indiscutable du traitement. Bien que reposant sur un petit échantillon de malades, ces données suggèrent que la thalidomide pourrait trouver une place utile dans le traitement de la GVH, peut-être spécifiquement sans sa forme chronique. thalidomide/maladie du greffon contre l'hôte/transplantation de moelle osseuse" @default.
- W2086403925 created "2016-06-24" @default.
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- W2086403925 date "1989-01-01" @default.
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- W2086403925 title "Thalidomide for the therapy of graft-versus-host disease following allogeneic bone marrow transplantation" @default.
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- W2086403925 doi "https://doi.org/10.1016/0753-3322(89)90089-9" @default.
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