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• W2086404403 abstract "The ability of RNA polymerase I to read through a promoter-bound transcription initiation factor (TIF) was assessed using a dimeric ribosomal RNA gene promoter. Transcription from the upstream promoter is unaffected by TIF bound to the downstream promoter; RNA polymerase I is freely able to read through DNA-bound TIF. In contrast, transcription from the downstream promoter is inhibited by the passage of RNA polymerase I. Readthrough by RNA polymerase I disrupts the downstream TIF-DNA complex, and alters the TIF footprint. A general function for sequences leading to transcription termination upstream of rRNA or other promoters may be the prevention of promoter occlusion in tandem arrays of genes." @default.
• W2086404403 created "2016-06-24" @default.
• W2086404403 creator A5022024302 @default.
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• W2086404403 date "1988-09-01" @default.
• W2086404403 modified "2023-09-26" @default.
• W2086404403 title "Promoter occlusion during ribosomal RNA transcription" @default.
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• W2086404403 doi "https://doi.org/10.1016/0092-8674(88)90113-4" @default.
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