Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086416610> ?p ?o ?g. }
- W2086416610 endingPage "200" @default.
- W2086416610 startingPage "195" @default.
- W2086416610 abstract "The enzyme catalase catalyzes the breakdown of hydrogen peroxide into oxygen and water. It is the main regulator of hydrogen peroxide metabolism. Hydrogen peroxide is a highly reactive small molecule formed as a natural byproducts of energy metabolism. Excessive concentrations may cause significant damages to protein, DNA, RNA and lipids. Low levels in muscle cells, facilitate insulin signaling. Acatalasemia is a result of the homozygous mutations in the catalase gene, has a worldwide distribution with 12 known mutations. Increased hydrogen peroxide, due to catalase deficiency, plays a role in the pathogenesis of several diseases such as diabetes mellitus. Diabetes mellitus is a disorder caused by multiple genetic and environmental factors. Examination of Hungarian diabetic and acatalasemic patients showed that an increased frequency of catalase gene mutations exists among diabetes patients. Inherited catalase deficiency may increase the risk of type 2 diabetes mellitus, especially for females. Early onset of type 2 diabetes occurs with inherited catalase deficiency. Low levels of SOD and glutathione peroxidase could contribute to complications caused by increased oxidative stress." @default.
- W2086416610 created "2016-06-24" @default.
- W2086416610 creator A5016187236 @default.
- W2086416610 creator A5064350754 @default.
- W2086416610 date "2012-09-01" @default.
- W2086416610 modified "2023-10-17" @default.
- W2086416610 title "Acatalasemia and diabetes mellitus" @default.
- W2086416610 cites W1543996619 @default.
- W2086416610 cites W1571399565 @default.
- W2086416610 cites W1668328580 @default.
- W2086416610 cites W1782880405 @default.
- W2086416610 cites W1921965616 @default.
- W2086416610 cites W1963799565 @default.
- W2086416610 cites W1966558949 @default.
- W2086416610 cites W1966621383 @default.
- W2086416610 cites W1967964480 @default.
- W2086416610 cites W1968991720 @default.
- W2086416610 cites W1971464256 @default.
- W2086416610 cites W1974057844 @default.
- W2086416610 cites W1975801075 @default.
- W2086416610 cites W1977983510 @default.
- W2086416610 cites W1981997439 @default.
- W2086416610 cites W1982899101 @default.
- W2086416610 cites W1987686493 @default.
- W2086416610 cites W1991437749 @default.
- W2086416610 cites W1992027693 @default.
- W2086416610 cites W1997048738 @default.
- W2086416610 cites W2000580922 @default.
- W2086416610 cites W2002449992 @default.
- W2086416610 cites W2002975285 @default.
- W2086416610 cites W2008760489 @default.
- W2086416610 cites W2009476974 @default.
- W2086416610 cites W2011041580 @default.
- W2086416610 cites W2016839547 @default.
- W2086416610 cites W2022852506 @default.
- W2086416610 cites W2024907202 @default.
- W2086416610 cites W2026455672 @default.
- W2086416610 cites W2030817463 @default.
- W2086416610 cites W2032856448 @default.
- W2086416610 cites W2035809929 @default.
- W2086416610 cites W2038232043 @default.
- W2086416610 cites W2039362293 @default.
- W2086416610 cites W2043107413 @default.
- W2086416610 cites W2043549608 @default.
- W2086416610 cites W2052645300 @default.
- W2086416610 cites W2055159605 @default.
- W2086416610 cites W2059037357 @default.
- W2086416610 cites W2060919923 @default.
- W2086416610 cites W2062963655 @default.
- W2086416610 cites W2064483915 @default.
- W2086416610 cites W2075001574 @default.
- W2086416610 cites W2076974161 @default.
- W2086416610 cites W2081348396 @default.
- W2086416610 cites W2083007831 @default.
- W2086416610 cites W2083208657 @default.
- W2086416610 cites W2085022569 @default.
- W2086416610 cites W2085429666 @default.
- W2086416610 cites W2087258435 @default.
- W2086416610 cites W2088012387 @default.
- W2086416610 cites W2091283255 @default.
- W2086416610 cites W2091478729 @default.
- W2086416610 cites W2097576853 @default.
- W2086416610 cites W2109069544 @default.
- W2086416610 cites W2110657098 @default.
- W2086416610 cites W2111370380 @default.
- W2086416610 cites W2120671198 @default.
- W2086416610 cites W2126191219 @default.
- W2086416610 cites W2127998841 @default.
- W2086416610 cites W2136573391 @default.
- W2086416610 cites W2140603619 @default.
- W2086416610 cites W2152656461 @default.
- W2086416610 cites W2163993386 @default.
- W2086416610 cites W2402561652 @default.
- W2086416610 cites W2790233152 @default.
- W2086416610 cites W347989178 @default.
- W2086416610 doi "https://doi.org/10.1016/j.abb.2012.02.005" @default.
- W2086416610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22365890" @default.
- W2086416610 hasPublicationYear "2012" @default.
- W2086416610 type Work @default.
- W2086416610 sameAs 2086416610 @default.
- W2086416610 citedByCount "52" @default.
- W2086416610 countsByYear W20864166102012 @default.
- W2086416610 countsByYear W20864166102013 @default.
- W2086416610 countsByYear W20864166102014 @default.
- W2086416610 countsByYear W20864166102015 @default.
- W2086416610 countsByYear W20864166102016 @default.
- W2086416610 countsByYear W20864166102017 @default.
- W2086416610 countsByYear W20864166102018 @default.
- W2086416610 countsByYear W20864166102019 @default.
- W2086416610 countsByYear W20864166102020 @default.
- W2086416610 countsByYear W20864166102021 @default.
- W2086416610 countsByYear W20864166102022 @default.
- W2086416610 countsByYear W20864166102023 @default.
- W2086416610 crossrefType "journal-article" @default.
- W2086416610 hasAuthorship W2086416610A5016187236 @default.
- W2086416610 hasAuthorship W2086416610A5064350754 @default.
- W2086416610 hasConcept C126322002 @default.
- W2086416610 hasConcept C134018914 @default.