Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086416770> ?p ?o ?g. }
- W2086416770 endingPage "1039" @default.
- W2086416770 startingPage "1028" @default.
- W2086416770 abstract "Epidermal growth factor (EGF), an endogenous mitogenic peptide, has recently been shown to be a potent vasoconstrictor of vascular smooth muscle. In view of its potential role in proliferative and inflammatory renal glomerular diseases, we examined the effects of EGF both on cultured rat mesangial cells and on in vivo glomerular hemodynamics. Mesangial cells possess specific, saturable EGF receptors of differing affinities, with Kd's of 0.1 and 1.7 nM, respectively. EGF produced a rapid increase in intracellular pH of 0.12 +/- 0.01 pH U, which was sodium dependent and amiloride inhibitable. The addition of EGF to mesangial cells cultured on either glass or dimethylpolysiloxane substratum induced reproducible cell contraction. Intrarenal EGF infusion did not affect systemic blood pressure or hematocrit but reversibly decreased GFR and renal blood flow from 4.19 +/- 0.33 to 3.33 +/- 0.26 and from 1.17 +/- 0.09 to 0.69 +/- 0.07 ml/min, respectively. Glomerular micropuncture confirmed decreases in single nephron plasma flow and in single nephron GFR (from 142 +/- 9 to 98 +/- 8 and from 51.6 +/- 11.7 to 28.5 +/- 3.5 nl/min, respectively) which were due to significant increases in both pre- and postglomerular arteriolar resistances (from 1.97 +/- 0.31 to 2.65 +/- 0.36 and from 1.19 +/- 0.11 to 2.00 +/- 0.15 10(10) dyn.s.cm-5 respectively) and to a significant decrease in the ultrafiltration coefficient, Kf, which fell from 0.100 +/- 0.019 to 0.031 +/- 0.007 nl/(s.mmHg). These studies demonstrate that mesangial cells possess specific receptors for EGF, and exposure of these cells to physiologic concentrations of EGF results in an in vitro functional response characterized by activation of Na+/H+ exchange and by resultant intracellular alkalinization, as well as by cell contraction. EGF administration in vivo significantly reduces the glomerular capillary ultrafiltration coefficient, Kf, which, in combination with EGF-induced constriction of both preglomerular and postglomerular arterioles, results in acute major reductions in the rates of glomerular filtration and perfusion." @default.
- W2086416770 created "2016-06-24" @default.
- W2086416770 creator A5011433645 @default.
- W2086416770 creator A5015521575 @default.
- W2086416770 creator A5018821154 @default.
- W2086416770 creator A5042782798 @default.
- W2086416770 date "1988-09-01" @default.
- W2086416770 modified "2023-09-25" @default.
- W2086416770 title "Evidence for glomerular actions of epidermal growth factor in the rat." @default.
- W2086416770 cites W1495442004 @default.
- W2086416770 cites W1501383613 @default.
- W2086416770 cites W1510058062 @default.
- W2086416770 cites W1518719712 @default.
- W2086416770 cites W1560333424 @default.
- W2086416770 cites W1628918243 @default.
- W2086416770 cites W1894641937 @default.
- W2086416770 cites W1947794470 @default.
- W2086416770 cites W1967125132 @default.
- W2086416770 cites W1973665038 @default.
- W2086416770 cites W1982251557 @default.
- W2086416770 cites W1985832800 @default.
- W2086416770 cites W1994076220 @default.
- W2086416770 cites W1996289114 @default.
- W2086416770 cites W1999514574 @default.
- W2086416770 cites W2001534689 @default.
- W2086416770 cites W2007719101 @default.
- W2086416770 cites W2008856307 @default.
- W2086416770 cites W2009496517 @default.
- W2086416770 cites W2011247974 @default.
- W2086416770 cites W2011486884 @default.
- W2086416770 cites W2020526327 @default.
- W2086416770 cites W2022996912 @default.
- W2086416770 cites W2024071649 @default.
- W2086416770 cites W2029312059 @default.
- W2086416770 cites W2033936610 @default.
- W2086416770 cites W2045332701 @default.
- W2086416770 cites W2057595921 @default.
- W2086416770 cites W2060664683 @default.
- W2086416770 cites W2066952572 @default.
- W2086416770 cites W2068548350 @default.
- W2086416770 cites W2070501693 @default.
- W2086416770 cites W2073478078 @default.
- W2086416770 cites W2083511059 @default.
- W2086416770 cites W2114402920 @default.
- W2086416770 cites W2135862279 @default.
- W2086416770 cites W2163454158 @default.
- W2086416770 cites W2171246715 @default.
- W2086416770 cites W2396102518 @default.
- W2086416770 doi "https://doi.org/10.1172/jci113659" @default.
- W2086416770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/303617" @default.
- W2086416770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3262122" @default.
- W2086416770 hasPublicationYear "1988" @default.
- W2086416770 type Work @default.
- W2086416770 sameAs 2086416770 @default.
- W2086416770 citedByCount "110" @default.
- W2086416770 countsByYear W20864167702012 @default.
- W2086416770 countsByYear W20864167702013 @default.
- W2086416770 countsByYear W20864167702014 @default.
- W2086416770 countsByYear W20864167702015 @default.
- W2086416770 countsByYear W20864167702016 @default.
- W2086416770 countsByYear W20864167702018 @default.
- W2086416770 countsByYear W20864167702019 @default.
- W2086416770 crossrefType "journal-article" @default.
- W2086416770 hasAuthorship W2086416770A5011433645 @default.
- W2086416770 hasAuthorship W2086416770A5015521575 @default.
- W2086416770 hasAuthorship W2086416770A5018821154 @default.
- W2086416770 hasAuthorship W2086416770A5042782798 @default.
- W2086416770 hasBestOaLocation W20864167701 @default.
- W2086416770 hasConcept C126322002 @default.
- W2086416770 hasConcept C134018914 @default.
- W2086416770 hasConcept C142225936 @default.
- W2086416770 hasConcept C159641895 @default.
- W2086416770 hasConcept C170493617 @default.
- W2086416770 hasConcept C178790620 @default.
- W2086416770 hasConcept C185592680 @default.
- W2086416770 hasConcept C2776362946 @default.
- W2086416770 hasConcept C2779608910 @default.
- W2086416770 hasConcept C2780091579 @default.
- W2086416770 hasConcept C2780368995 @default.
- W2086416770 hasConcept C2780959883 @default.
- W2086416770 hasConcept C2781231759 @default.
- W2086416770 hasConcept C3018920779 @default.
- W2086416770 hasConcept C537181965 @default.
- W2086416770 hasConcept C71924100 @default.
- W2086416770 hasConcept C86803240 @default.
- W2086416770 hasConceptScore W2086416770C126322002 @default.
- W2086416770 hasConceptScore W2086416770C134018914 @default.
- W2086416770 hasConceptScore W2086416770C142225936 @default.
- W2086416770 hasConceptScore W2086416770C159641895 @default.
- W2086416770 hasConceptScore W2086416770C170493617 @default.
- W2086416770 hasConceptScore W2086416770C178790620 @default.
- W2086416770 hasConceptScore W2086416770C185592680 @default.
- W2086416770 hasConceptScore W2086416770C2776362946 @default.
- W2086416770 hasConceptScore W2086416770C2779608910 @default.
- W2086416770 hasConceptScore W2086416770C2780091579 @default.
- W2086416770 hasConceptScore W2086416770C2780368995 @default.
- W2086416770 hasConceptScore W2086416770C2780959883 @default.
- W2086416770 hasConceptScore W2086416770C2781231759 @default.