FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086431073> ?p ?o ?g. }

• W2086431073 endingPage "2642" @default.
• W2086431073 startingPage "2639" @default.
• W2086431073 abstract "In this study, we elucidated a small molecule inhibitor on viral protein NS5B identified through a high-throughput screening strategy using optical nanoparticle-based RNA oligonucleotide. We have previously shown that quantum dots (QDs)-RNA oligonucleotide can specifically recognize the HCV viral proteins. We have also demonstrated that conjugated QDs-RNA oligonucleotide can specifically and sensitively interact with designed biochips [1,2]. Among the flavonoids examined, (-)-epigallocatechin gallate (EGCG) demonstrated a remarkable inhibition activity on HCV viral protein, NS5B. (-)-Epigallocatechin gallate, at 0.005 μg mL(-1) or more, concentration-dependently attenuated the binding affinity on a designed biochip as evidenced by QDs-RNA oligonucleotide. At a concentration of 0.1 μg mL(-1), (-)-epigallocatechin gallate showed a 50% inhibition activity on QDs-RNA oligonucleotide biochip assay. We screened a small molecule inhibitor on the viral protein, NS5B, identified through a high-throughput screening strategy using on-chip optical nanoparticle-based RNA oligonucleotide on chip. In this designed strategy, the convenient and efficient screening and development of an on-chip viral protein inhibitor using a QDs-RNA oligonucleotide assay is achievable with high sensitivity and simplicity. In addition, this platform is expected to be applicable toward the inhibitor screening of other types of diseases." @default.
• W2086431073 created "2016-06-24" @default.
• W2086431073 creator A5042309997 @default.
• W2086431073 creator A5058935068 @default.
• W2086431073 date "2011-10-01" @default.
• W2086431073 modified "2023-10-06" @default.
• W2086431073 title "(−)-Epigallocatechin gallate inhibits hepatitis C virus (HCV) viral protein NS5B" @default.
• W2086431073 cites W1965978688 @default.
• W2086431073 cites W1968906564 @default.
• W2086431073 cites W1969703082 @default.
• W2086431073 cites W1970389489 @default.
• W2086431073 cites W1972019991 @default.
• W2086431073 cites W1972097935 @default.
• W2086431073 cites W1973596010 @default.
• W2086431073 cites W1989023011 @default.
• W2086431073 cites W1992597005 @default.
• W2086431073 cites W1999307133 @default.
• W2086431073 cites W2004417113 @default.
• W2086431073 cites W2028835178 @default.
• W2086431073 cites W2071352029 @default.
• W2086431073 cites W2086070404 @default.
• W2086431073 cites W2086189875 @default.
• W2086431073 cites W2087075582 @default.
• W2086431073 cites W2089456358 @default.
• W2086431073 cites W2096426963 @default.
• W2086431073 cites W2096738896 @default.
• W2086431073 cites W2098897538 @default.
• W2086431073 cites W2100837269 @default.
• W2086431073 cites W2103498170 @default.
• W2086431073 cites W2104478003 @default.
• W2086431073 cites W2108810815 @default.
• W2086431073 cites W2110524342 @default.
• W2086431073 cites W2127390105 @default.
• W2086431073 cites W2130409253 @default.
• W2086431073 cites W2152092798 @default.
• W2086431073 cites W2166906664 @default.
• W2086431073 cites W2911273765 @default.
• W2086431073 cites W4293247451 @default.
• W2086431073 doi "https://doi.org/10.1016/j.talanta.2011.08.035" @default.
• W2086431073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21962695" @default.
• W2086431073 hasPublicationYear "2011" @default.
• W2086431073 type Work @default.
• W2086431073 sameAs 2086431073 @default.
• W2086431073 citedByCount "26" @default.
• W2086431073 countsByYear W20864310732012 @default.
• W2086431073 countsByYear W20864310732013 @default.
• W2086431073 countsByYear W20864310732014 @default.
• W2086431073 countsByYear W20864310732015 @default.
• W2086431073 countsByYear W20864310732016 @default.
• W2086431073 countsByYear W20864310732018 @default.
• W2086431073 countsByYear W20864310732020 @default.
• W2086431073 countsByYear W20864310732021 @default.
• W2086431073 countsByYear W20864310732022 @default.
• W2086431073 crossrefType "journal-article" @default.
• W2086431073 hasAuthorship W2086431073A5042309997 @default.
• W2086431073 hasAuthorship W2086431073A5058935068 @default.
• W2086431073 hasConcept C104317684 @default.
• W2086431073 hasConcept C129312508 @default.
• W2086431073 hasConcept C135763542 @default.
• W2086431073 hasConcept C153911025 @default.
• W2086431073 hasConcept C159047783 @default.
• W2086431073 hasConcept C161624437 @default.
• W2086431073 hasConcept C185592680 @default.
• W2086431073 hasConcept C2522874641 @default.
• W2086431073 hasConcept C2776408679 @default.
• W2086431073 hasConcept C2781426373 @default.
• W2086431073 hasConcept C2781463415 @default.
• W2086431073 hasConcept C552990157 @default.
• W2086431073 hasConcept C55493867 @default.
• W2086431073 hasConcept C60644358 @default.
• W2086431073 hasConcept C67705224 @default.
• W2086431073 hasConcept C86803240 @default.
• W2086431073 hasConcept C87892846 @default.
• W2086431073 hasConceptScore W2086431073C104317684 @default.
• W2086431073 hasConceptScore W2086431073C129312508 @default.
• W2086431073 hasConceptScore W2086431073C135763542 @default.
• W2086431073 hasConceptScore W2086431073C153911025 @default.
• W2086431073 hasConceptScore W2086431073C159047783 @default.
• W2086431073 hasConceptScore W2086431073C161624437 @default.
• W2086431073 hasConceptScore W2086431073C185592680 @default.
• W2086431073 hasConceptScore W2086431073C2522874641 @default.
• W2086431073 hasConceptScore W2086431073C2776408679 @default.
• W2086431073 hasConceptScore W2086431073C2781426373 @default.
• W2086431073 hasConceptScore W2086431073C2781463415 @default.
• W2086431073 hasConceptScore W2086431073C552990157 @default.
• W2086431073 hasConceptScore W2086431073C55493867 @default.
• W2086431073 hasConceptScore W2086431073C60644358 @default.
• W2086431073 hasConceptScore W2086431073C67705224 @default.
• W2086431073 hasConceptScore W2086431073C86803240 @default.
• W2086431073 hasConceptScore W2086431073C87892846 @default.
• W2086431073 hasFunder F4320322109 @default.
• W2086431073 hasFunder F4320322349 @default.
• W2086431073 hasIssue "5" @default.
• W2086431073 hasLocation W20864310731 @default.
• W2086431073 hasLocation W20864310732 @default.
• W2086431073 hasOpenAccess W2086431073 @default.
• W2086431073 hasPrimaryLocation W20864310731 @default.
• W2086431073 hasRelatedWork W1552666296 @default.

• next