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- W2086442005 abstract "K + contractures were elicited in small bundles of tonic skeletal muscle fibres of the frog. Adrenaline (1 μM) increased the amplitude of K + contractures in a [K + ] o -dependent manner: maximal effects were produced between 20 and 60 mM [K + ] o . In contrast, we found no effect of adrenaline on K + contractures of twitch fibres. The potentiating effect of adrenaline depended on [Ca 2+ ] o . Increasing [Ca 2+ ] o from 1.8 to 10 mM doubled the positive inotropic effect of adrenaline. In a nominally Ca 2+ free saline, adrenaline had no potentiating effect. The Ca 2+ channel blockers nifedipine (20 μM) and Ni 2+ (1.8 mM) reversibly reduced the amplitude of the tonic phase of K + contractures and blocked the potentiation by adrenaline. The mechanical effects of adrenaline cannot be explained by changes in the membrane potential, as revealed by intracellular recordings at several [K + ] o . It Was concluded that the potentiating effect of adrenaline in tonic muscle fibres of the frog may be mediated through Ca 2+ channels.Key words: adrenaline, slow muscle, excitation–contraction coupling, potassium contractures." @default.
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- W2086442005 title "Positive inotropic effect of adrenaline on potassium contractures in tonic skeletal muscle fibres of the frog" @default.
- W2086442005 doi "https://doi.org/10.1139/y94-227" @default.
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