FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086458095> ?p ?o ?g. }

• W2086458095 endingPage "332" @default.
• W2086458095 startingPage "323" @default.
• W2086458095 abstract "Intentional inhalation and occupational exposure are two ways humans are exposed to thinner, a widely employed solvent in industry. Inhalation of thinner induces toxic effects in various organs, with the cerebellum being one of the most affected structures of the CNS. The aim of this work was to describe specific structural alterations of cerebellum Purkinje cells in rats following exposure to thinner for 16 weeks. A histological analysis of the cerebellum of solvent-exposed rats revealed swollen Purkinje cell dendrites surrounded by empty space, and electronic microscopy showed an increase in the number of subsurface cisterns (SSCs) within their dendritic processes. After a period of non-exposure, the number of SSCs decreased without reaching normal levels, suggesting a degree of plasticity. Purkinje cell SSCs, which are derived from smooth endoplasmic reticulum, contain inositol trisphosphate receptors (IP3Rs), ryanodine receptors (RR), and a recently identified characteristic cluster of large conductance calcium-activated potassium (BKCa) channels. We found that SSCs in Purkinje cell dendrites were closely associated with mitochondria, and immunofluorescence microscopy showed higher levels of RR and calbindin receptors (CB), in Purkinje cells of exposed than normal rats. These changes are probably related to behavioral manifestations of cerebellar alterations, such as imbalance and ataxia, consistent with the suggested involvement of increases in SSCs in ataxia in rats and humans. This increase in SSCs, taken together with the localization of RR, IP3R and BKCa proteins in this structure, suggests altered intracellular calcium-buffering processes in the Purkinje cells of thinner-exposed rats." @default.
• W2086458095 created "2016-06-24" @default.
• W2086458095 creator A5004393791 @default.
• W2086458095 creator A5015060549 @default.
• W2086458095 creator A5025739668 @default.
• W2086458095 creator A5057536422 @default.
• W2086458095 creator A5079981196 @default.
• W2086458095 date "2014-09-01" @default.
• W2086458095 modified "2023-10-08" @default.
• W2086458095 title "Subsurface cistern (SSC) proliferation in Purkinje cells of the rat cerebellum in response to acute and chronic exposure to paint thinner: A light and electron microscopy study" @default.
• W2086458095 cites W1504647009 @default.
• W2086458095 cites W1524844064 @default.
• W2086458095 cites W1554245708 @default.
• W2086458095 cites W1561980328 @default.
• W2086458095 cites W1602610405 @default.
• W2086458095 cites W1952906612 @default.
• W2086458095 cites W1965559326 @default.
• W2086458095 cites W1968872540 @default.
• W2086458095 cites W1969241958 @default.
• W2086458095 cites W1970189295 @default.
• W2086458095 cites W1970263992 @default.
• W2086458095 cites W1981504301 @default.
• W2086458095 cites W1983430986 @default.
• W2086458095 cites W1992584198 @default.
• W2086458095 cites W1995237824 @default.
• W2086458095 cites W2007261892 @default.
• W2086458095 cites W2010751802 @default.
• W2086458095 cites W2012751980 @default.
• W2086458095 cites W2014888086 @default.
• W2086458095 cites W2020372983 @default.
• W2086458095 cites W2034235846 @default.
• W2086458095 cites W2035749558 @default.
• W2086458095 cites W2035889992 @default.
• W2086458095 cites W2037180842 @default.
• W2086458095 cites W2045804449 @default.
• W2086458095 cites W2047407364 @default.
• W2086458095 cites W2060093203 @default.
• W2086458095 cites W2067895005 @default.
• W2086458095 cites W2073149784 @default.
• W2086458095 cites W2074890054 @default.
• W2086458095 cites W2084512076 @default.
• W2086458095 cites W2087188546 @default.
• W2086458095 cites W2094128426 @default.
• W2086458095 cites W2113558868 @default.
• W2086458095 cites W2141035202 @default.
• W2086458095 cites W2162652424 @default.
• W2086458095 cites W2162725134 @default.
• W2086458095 cites W2211834126 @default.
• W2086458095 cites W2414474844 @default.
• W2086458095 doi "https://doi.org/10.1016/j.etp.2014.04.003" @default.
• W2086458095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24820124" @default.
• W2086458095 hasPublicationYear "2014" @default.
• W2086458095 type Work @default.
• W2086458095 sameAs 2086458095 @default.
• W2086458095 citedByCount "5" @default.
• W2086458095 countsByYear W20864580952017 @default.
• W2086458095 countsByYear W20864580952018 @default.
• W2086458095 countsByYear W20864580952023 @default.
• W2086458095 crossrefType "journal-article" @default.
• W2086458095 hasAuthorship W2086458095A5004393791 @default.
• W2086458095 hasAuthorship W2086458095A5015060549 @default.
• W2086458095 hasAuthorship W2086458095A5025739668 @default.
• W2086458095 hasAuthorship W2086458095A5057536422 @default.
• W2086458095 hasAuthorship W2086458095A5079981196 @default.
• W2086458095 hasConcept C126322002 @default.
• W2086458095 hasConcept C134018914 @default.
• W2086458095 hasConcept C142724271 @default.
• W2086458095 hasConcept C158617107 @default.
• W2086458095 hasConcept C169760540 @default.
• W2086458095 hasConcept C170493617 @default.
• W2086458095 hasConcept C181080969 @default.
• W2086458095 hasConcept C185592680 @default.
• W2086458095 hasConcept C2778472085 @default.
• W2086458095 hasConcept C2779652256 @default.
• W2086458095 hasConcept C2780906641 @default.
• W2086458095 hasConcept C55493867 @default.
• W2086458095 hasConcept C71924100 @default.
• W2086458095 hasConcept C79879829 @default.
• W2086458095 hasConcept C86803240 @default.
• W2086458095 hasConcept C95444343 @default.
• W2086458095 hasConceptScore W2086458095C126322002 @default.
• W2086458095 hasConceptScore W2086458095C134018914 @default.
• W2086458095 hasConceptScore W2086458095C142724271 @default.
• W2086458095 hasConceptScore W2086458095C158617107 @default.
• W2086458095 hasConceptScore W2086458095C169760540 @default.
• W2086458095 hasConceptScore W2086458095C170493617 @default.
• W2086458095 hasConceptScore W2086458095C181080969 @default.
• W2086458095 hasConceptScore W2086458095C185592680 @default.
• W2086458095 hasConceptScore W2086458095C2778472085 @default.
• W2086458095 hasConceptScore W2086458095C2779652256 @default.
• W2086458095 hasConceptScore W2086458095C2780906641 @default.
• W2086458095 hasConceptScore W2086458095C55493867 @default.
• W2086458095 hasConceptScore W2086458095C71924100 @default.
• W2086458095 hasConceptScore W2086458095C79879829 @default.
• W2086458095 hasConceptScore W2086458095C86803240 @default.
• W2086458095 hasConceptScore W2086458095C95444343 @default.
• W2086458095 hasIssue "7" @default.
• W2086458095 hasLocation W20864580951 @default.

• next