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- W2086459628 abstract "Stimulation of cell-surface seven-transmembrane receptors (7TMRs) elicits biological responses to a wide range of extracellular signals, including many hormones. Classically, heterotrimeric GTP-binding proteins (G proteins) are recruited to the activated conformation of 7TMRs. Only two other families of protein have this remarkable characteristic: G-protein-coupled receptor kinases and beta-arrestins. These two protein families have long been known to have a central and coordinated role in the desensitization of G protein activation by 7TMRs. In addition, G-protein-coupled receptor kinases and beta-arrestins are involved in an increasing number of interactions with non-receptor proteins, broadening the variety of their cellular functions. These newly appreciated attributes of these two families of protein highlight their unique ability to coordinate the various aspects of 7TMR functions." @default.
- W2086459628 created "2016-06-24" @default.
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- W2086459628 date "2006-05-01" @default.
- W2086459628 modified "2023-10-17" @default.
- W2086459628 title "GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling" @default.
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- W2086459628 doi "https://doi.org/10.1016/j.tem.2006.03.008" @default.
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