FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086465998> ?p ?o ?g. }

• W2086465998 endingPage "687" @default.
• W2086465998 startingPage "678" @default.
• W2086465998 abstract "MRI is commonly used to determine the location and extent of cerebral gliomas. We investigated whether the diagnostic accuracy of MRI could be improved by the additional use of PET with the amino acid O-(2-[18F]fluoroethyl)-l-tyrosine (FET). In a prospective study, PET with FET and MRI was performed in 31 patients with suspected cerebral gliomas. PET and MRIs were co-registered and 52 neuronavigated tissue biopsies were taken from lesions with both abnormal MRI signal and increased FET uptake (match), as well as from areas with abnormal MR signal but normal FET uptake or vice versa (mismatch). Biopsy sites were labelled by intracerebral titanium pellets. The diagnostic performance for the identification of cellular tumour tissue was analysed for either MRI alone or MRI combined with FET PET using alternative free response receiver operating characteristic curves (ROCs). Histologically, 26 biopsy samples corresponded to cellular glioma tissue and 26 to peritumoral brain tissue. The diagnostic performance, as determined by the area under the ROC curve (Az), was Az = 0.80 for MRI alone and Az = 0.98 for the combined MRI and FET PET approach (P < 0.001). MRI yielded a sensitivity of 96% for the detection of tumour tissue but a specificity of only 53%, and combined use of MRI and FET PET yielded a sensitivity of 93% and a specificity of 94%. Combined use of MRI and FET PET in patients with cerebral gliomas significantly improves the identification of cellular glioma tissue and allows definite histological tumour diagnosis. Thus, our findings may have considerable impact on target selection for diagnostic biopsies as well as therapy planning." @default.
• W2086465998 created "2016-06-24" @default.
• W2086465998 creator A5001461777 @default.
• W2086465998 creator A5014129073 @default.
• W2086465998 creator A5017291556 @default.
• W2086465998 creator A5036115118 @default.
• W2086465998 creator A5060901047 @default.
• W2086465998 creator A5062516261 @default.
• W2086465998 creator A5064882474 @default.
• W2086465998 creator A5075801834 @default.
• W2086465998 creator A5087646992 @default.
• W2086465998 date "2005-01-05" @default.
• W2086465998 modified "2023-10-11" @default.
• W2086465998 title "O-(2-[18F]fluoroethyl)-L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas" @default.
• W2086465998 cites W150342960 @default.
• W2086465998 cites W1536266814 @default.
• W2086465998 cites W1853650156 @default.
• W2086465998 cites W1950512608 @default.
• W2086465998 cites W1964123950 @default.
• W2086465998 cites W1964421702 @default.
• W2086465998 cites W1965932759 @default.
• W2086465998 cites W1967643057 @default.
• W2086465998 cites W1975556207 @default.
• W2086465998 cites W1982847419 @default.
• W2086465998 cites W1992580944 @default.
• W2086465998 cites W1993237034 @default.
• W2086465998 cites W1999778470 @default.
• W2086465998 cites W2002322242 @default.
• W2086465998 cites W2012215869 @default.
• W2086465998 cites W2020420274 @default.
• W2086465998 cites W2026160939 @default.
• W2086465998 cites W2031849543 @default.
• W2086465998 cites W2032443466 @default.
• W2086465998 cites W2039881069 @default.
• W2086465998 cites W2045969014 @default.
• W2086465998 cites W2067466459 @default.
• W2086465998 cites W2073616825 @default.
• W2086465998 cites W2086486486 @default.
• W2086465998 cites W2090298833 @default.
• W2086465998 cites W2095316281 @default.
• W2086465998 cites W2098626197 @default.
• W2086465998 cites W2099742943 @default.
• W2086465998 cites W2122317907 @default.
• W2086465998 cites W2122356527 @default.
• W2086465998 cites W2124698656 @default.
• W2086465998 cites W2131494549 @default.
• W2086465998 cites W2140866432 @default.
• W2086465998 cites W2141495000 @default.
• W2086465998 cites W2146933354 @default.
• W2086465998 cites W2150340231 @default.
• W2086465998 cites W2153670940 @default.
• W2086465998 cites W2156658337 @default.
• W2086465998 cites W2163557066 @default.
• W2086465998 cites W2338175682 @default.
• W2086465998 cites W58578266 @default.
• W2086465998 cites W2480059540 @default.
• W2086465998 doi "https://doi.org/10.1093/brain/awh399" @default.
• W2086465998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15689365" @default.
• W2086465998 hasPublicationYear "2005" @default.
• W2086465998 type Work @default.
• W2086465998 sameAs 2086465998 @default.
• W2086465998 citedByCount "546" @default.
• W2086465998 countsByYear W20864659982012 @default.
• W2086465998 countsByYear W20864659982013 @default.
• W2086465998 countsByYear W20864659982014 @default.
• W2086465998 countsByYear W20864659982015 @default.
• W2086465998 countsByYear W20864659982016 @default.
• W2086465998 countsByYear W20864659982017 @default.
• W2086465998 countsByYear W20864659982018 @default.
• W2086465998 countsByYear W20864659982019 @default.
• W2086465998 countsByYear W20864659982020 @default.
• W2086465998 countsByYear W20864659982021 @default.
• W2086465998 countsByYear W20864659982022 @default.
• W2086465998 countsByYear W20864659982023 @default.
• W2086465998 crossrefType "journal-article" @default.
• W2086465998 hasAuthorship W2086465998A5001461777 @default.
• W2086465998 hasAuthorship W2086465998A5014129073 @default.
• W2086465998 hasAuthorship W2086465998A5017291556 @default.
• W2086465998 hasAuthorship W2086465998A5036115118 @default.
• W2086465998 hasAuthorship W2086465998A5060901047 @default.
• W2086465998 hasAuthorship W2086465998A5062516261 @default.
• W2086465998 hasAuthorship W2086465998A5064882474 @default.
• W2086465998 hasAuthorship W2086465998A5075801834 @default.
• W2086465998 hasAuthorship W2086465998A5087646992 @default.
• W2086465998 hasConcept C126322002 @default.
• W2086465998 hasConcept C126838900 @default.
• W2086465998 hasConcept C142724271 @default.
• W2086465998 hasConcept C143409427 @default.
• W2086465998 hasConcept C2775934546 @default.
• W2086465998 hasConcept C2778227246 @default.
• W2086465998 hasConcept C2989005 @default.
• W2086465998 hasConcept C502942594 @default.
• W2086465998 hasConcept C58471807 @default.
• W2086465998 hasConcept C71924100 @default.
• W2086465998 hasConceptScore W2086465998C126322002 @default.
• W2086465998 hasConceptScore W2086465998C126838900 @default.
• W2086465998 hasConceptScore W2086465998C142724271 @default.
• W2086465998 hasConceptScore W2086465998C143409427 @default.

• next