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• W2086474057 abstract "The paraneoplastic neurologic disorders target several families of neuron-specific RNA binding proteins (RNABPs), revealing that there are unique aspects of gene expression regulation in the mammalian brain. Here, we used HITS-CLIP to determine robust binding sites targeted by the neuronal Elav-like (nElavl) RNABPs. Surprisingly, nElav protein binds preferentially to GU-rich sequences in vivo and in vitro, with secondary binding to AU-rich sequences. nElavl null mice were used to validate the consequence of these binding events in the brain, demonstrating that they bind intronic sequences in a position dependent manner to regulate alternative splicing and to 3'UTR sequences to regulate mRNA levels. These controls converge on the glutamate synthesis pathway in neurons; nElavl proteins are required to maintain neurotransmitter glutamate levels, and the lack of nElavl leads to spontaneous epileptic seizure activity. The genome-wide analysis of nElavl targets reveals that one function of neuron-specific RNABPs is to control excitation-inhibition balance in the brain." @default.
• W2086474057 created "2016-06-24" @default.
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• W2086474057 date "2012-09-01" @default.
• W2086474057 modified "2023-10-12" @default.
• W2086474057 title "Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability" @default.
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• W2086474057 doi "https://doi.org/10.1016/j.neuron.2012.07.009" @default.
• W2086474057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3517991" @default.
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