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- W2086492121 abstract "SUMMARY Studies of cerebral oxidative metabolism were carried out by phosphorous magnetic resonance spectroscopy during the first week of life in 52 infants with clinical and/or biochemical evidence of birth asphyxia. 15 infants died and the 37 survivors were assessed by a wide range of neurodevelopmental tests at one year of age. The minimum recorded values for cerebral phosphocreatine/inorganic phosphate concentration ratio (an index of oxidative metabolism) were related to outcome. The results showed a significant relation between the extent of derangement of oxidative metabolism and the severity of adverse outcomes, including death, neurodevelopmental impairment and reduced head growth. RÉSUMÉ Relation entre le métabolisme oxydatif cérébral après asphyxie à la naissance, et le devenir neurodéveloppemental, la croissance cérébrale à un an Des études du métabolisme oxydatif cérébral par spectroscopic de résonance magnétique au phosphore ont été entreprises durant la première semaine de vie chez 52 nourrissons présentant une évidence clinique et/ou biochimique d'asphyxie à la naissance. 15 nourrissons moururent et les 37 survivants subirent de nombreux tests neurodéveloppementaux à l'âge d'un an. Les taux minima enregistrés pour le rapport de concentration phosphocréatine/phosphates inorganiques (index de métabolisme oxydatif) furent reliés au devenir. Les résultats montrèrent une relation significative entre l'importance de la perturbation du métabolisme oxydatif et la gravité des devenirs négatifs, incluant le décès, le retard neurodéveloppemental et la réduction de la croissance cranienne. ZUSAMMENFASSUNG Beziehung zwischen oxydativem Hirnstoffwechsel nach Geburtsasphyxie und entwicklungsneurologischem Befund und Hirnentwicklung im Alter von einem Jahr Bei 52 Kindern mit klinischem und/oder biochemischem Hinweis auf eine Geburtsasphyxie wurden in der ersten Lebenswoche anhand der Phosphor-MRS Untersuchungen des oxydativen Hirnstoff-wechsels durchgeführt. 15 Kinder starben und die 37 Überlebenden wurden im Alter von einem Jahr mit einer Batterie von entwicklungsneurologischen Tests untersucht. Die niedrigsten Werte für das Verhältnis von cerebralem Phosphokreatinin/inorganischem Phosphat (ein Index für oxydativen Metabolismus) wurden zum Endbefund in Relation gestellt. Die Ergebnisse zeigten eine signifikante Beziehung zwischen den Störungen des oxydativen Metabolismus und dem Schweregrad der pathologischen Befunde, die Tod, entwicklungsneurologische Störungen und vermindertes Kopfwachtum beinhalteten. RESUMEN Relación entre el metabolismo oxidativo cerebral después de una asfixia de parto y el desarrollo neuroevolutivo y el crecimiento del cerebral año de edad Se realizaron estudios del metabolismo oxidativo cerebral utilizando la espectroscopia de resonancia magnética con fósforo durante la primera semana de vida en 52 niños lactantes con evidencia clínica y/o bioquímica de asfixia al nacer. 15 lactantes murieron y los 37 supervivientes fueron evaluados con un amplio abanico de tests de neurodesarrollo al año de edad. Los valores minimos registrados de la relación en el cerebro de fosfocreatina/fosfato inorgánico (indice de metabolismo oxidativo) se relacionaron con el curso seguido. Los resultados mostraron una relación significativa entre la extension de la alteración del metabolismo oxidativo y la gravedad de los cursos posteriores adversos, incluyendo el exitus, la alteración del neurodesarrollo y la reducción en el crecimiento de la cabeza." @default.
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- W2086492121 date "2008-11-12" @default.
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- W2086492121 title "RELATION BETWEEN CEREBRAL OXIDATIVE METABOLISM FOLLOWING BIRTH ASPHYXIA, AND NEURODEVELOPMENTAL OUTCOME AND BRAIN GROWTH AT ONE YEAR" @default.
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