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• W2086495308 abstract "1. 5,7-Dinitroindazole was extensively metabolized in both rats and mice. The principal biotransformations were nitro group reduction and aromatic hydroxylation.2. Selective reduction of the 7-nitro group to yield the 7-amino derivative occurred in both species in vivo. The same specificity of reduction was evident when dinitroindazole was incubated with a mixed culture of rat faecal microorganisms.3. A species difference in conjugation was found. In the mouse the major urinary excretion product was the N-glucuronide of the 7-amino derivative but this was not found in rat urine, acetylation of the 7-amino group being the preferred biosynthetic reaction.4. This 7-acetamido derivative is the probable precursor of two other metabolites in the rat. One of these has been identified as 3-hydroxy-5-nitro-7-acetamidoindazole and the other may be an N-hydroxylated derivative." @default.
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• W2086495308 date "1973-01-01" @default.
• W2086495308 modified "2023-10-17" @default.
• W2086495308 title "The Metabolism of 5,7-Dinitroindazole in the Mouse and the Rat" @default.
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• W2086495308 doi "https://doi.org/10.3109/00498257309151539" @default.
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