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• W2086505124 abstract "Maturation and maintenance of the intracellular vacuole in which Salmonella replicates is controlled by virulence proteins including the type III secretion system encoded by Salmonella pathogenicity island 2 (SPI-2). Here, we show that, several hours after bacterial uptake into different host cell types, Salmonella induces the formation of an F-actin meshwork around bacterial vacuoles. This structure is assembled de novo from the cellular G-actin pool in close proximity to the Salmonella vacuolar membrane. We demonstrate that the phenomenon does not require the Inv/Spa type III secretion system or cognate effector proteins, which induce actin polymerization during bacterial invasion, but does require a functional SPI-2 type III secretion system, which plays an important role in intracellular replication and systemic infection in mice. Treatment with actin-depolymerizing agents significantly inhibited intramacrophage replication of wild-type Salmonella typhimurium. Furthermore, after this treatment, wild-type bacteria were released into the host cell cytoplasm, whereas SPI-2 mutant bacteria remained within vacuoles. We conclude that actin assembly plays an important role in the establishment of an intracellular niche that sustains bacterial growth." @default.
• W2086505124 created "2016-06-24" @default.
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• W2086505124 date "2001-08-01" @default.
• W2086505124 modified "2023-10-18" @default.
• W2086505124 title "Remodelling of the actin cytoskeleton is essential for replication of intravacuolar Salmonella" @default.
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• W2086505124 doi "https://doi.org/10.1046/j.1462-5822.2001.00141.x" @default.
• W2086505124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11488817" @default.
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