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- W2086512091 endingPage "633" @default.
- W2086512091 startingPage "633" @default.
- W2086512091 abstract "Travoprost is a prostaglandin analogue widely used for reducing intraocular pressure (IOP) in patients affected with glaucoma and ocular hypertension. It exerts its ocular hypotensive effect through the prostaglandin FP receptors, located in the ciliary muscle and the trabecular meshwork. Several studies have shown that topical administration of travoprost induces a mean IOP reduction ranging from 25% to 32%, and sustained throughout the 24-hour cycle. When compared with timolol, travoprost is more effective at reducing IOP, while generally no difference has been found in the head-to-head comparison with other prostaglandin analogues. The fixed combination of travoprost and timolol has demonstrated a hypotensive efficacy comparable to the concomitant administration of the two drugs. Recently, a new preservative-free formulation of travoprost 0.004% has been marketed for reducing tolerability-related problems in subjects affected with ocular surface disease. Low rates of topical and systemic adverse reactions, strong ocular hypotensive efficacy, and once-a-day dosing make travoprost a first-line treatment for patients affected with elevated IOP." @default.
- W2086512091 created "2016-06-24" @default.
- W2086512091 creator A5015884388 @default.
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- W2086512091 creator A5051649943 @default.
- W2086512091 creator A5062465788 @default.
- W2086512091 date "2015-04-01" @default.
- W2086512091 modified "2023-10-16" @default.
- W2086512091 title "Safety and efficacy of travoprost solution for the treatment of elevated intraocular pressure" @default.
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