FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086513675> ?p ?o ?g. }

• W2086513675 endingPage "890" @default.
• W2086513675 startingPage "884" @default.
• W2086513675 abstract "Differentiation of embryonic stem (ES) cells into embryoid bodies (EBs) provides an in vitro system for the study of early lineage determination during mammalian development. We have previously reported that there are 247 CpG islands that potentially have tissue-dependent and differentially methylated regions (T-DMRs). This provided evidence that the formation of DNA methylation patterns at CpG islands is a crucial epigenetic event underlying mammalian development. Here we present an analysis by the restriction landmark genomic scanning (RLGS) using NotI as a landmark enzyme of the genome-wide methylation status of CpG islands of ES cells and EBs and of teratomas produced from ES cells. These results are considered in relation to the methylation status of CpG islands of genomic DNA from normal fetus (10.5dpc) and adult tissues. We have prepared a DNA methylation panel that consists of 259 T-DMRs and includes novel T-DMRs that are distinctly methylated or unmethylated in the teratomas. The DNA methylation pattern was complex and differed for the ES cells, EBs, and teratomas, providing evidence that differentiation of cells involves both de novo DNA methylation as well as demethylation. Comparison of the numbers of T-DMRs, that were differentially methylated or unmethylated among the cells and tissue types studied, revealed that the teratomas were the most epigenetically different from ES cells. Thus, analysis of the DNA methylation profiles prepared in this study provides new insights into the differentiation of ES cells and development of fetus, EB, teratoma, and somatic tissues." @default.
• W2086513675 created "2016-06-24" @default.
• W2086513675 creator A5018955901 @default.
• W2086513675 creator A5035804617 @default.
• W2086513675 creator A5037332134 @default.
• W2086513675 creator A5043144221 @default.
• W2086513675 creator A5046388572 @default.
• W2086513675 creator A5052070829 @default.
• W2086513675 creator A5059173679 @default.
• W2086513675 date "2003-11-01" @default.
• W2086513675 modified "2023-10-15" @default.
• W2086513675 title "Genome-wide analysis of DNA methylation status of CpG islands in embryoid bodies, teratomas, and fetuses" @default.
• W2086513675 cites W1556996865 @default.
• W2086513675 cites W1821797507 @default.
• W2086513675 cites W1982056215 @default.
• W2086513675 cites W1984680322 @default.
• W2086513675 cites W1989742405 @default.
• W2086513675 cites W1992924696 @default.
• W2086513675 cites W1996782393 @default.
• W2086513675 cites W1999510229 @default.
• W2086513675 cites W2001694119 @default.
• W2086513675 cites W2004818887 @default.
• W2086513675 cites W2013674741 @default.
• W2086513675 cites W2036078075 @default.
• W2086513675 cites W2043310127 @default.
• W2086513675 cites W2045187147 @default.
• W2086513675 cites W2047100086 @default.
• W2086513675 cites W2057159461 @default.
• W2086513675 cites W2062219202 @default.
• W2086513675 cites W2068914809 @default.
• W2086513675 cites W2078028724 @default.
• W2086513675 cites W2079240347 @default.
• W2086513675 cites W2079625772 @default.
• W2086513675 cites W2083624971 @default.
• W2086513675 cites W2085862124 @default.
• W2086513675 cites W2090092852 @default.
• W2086513675 cites W2090357268 @default.
• W2086513675 cites W2091658754 @default.
• W2086513675 cites W2120810945 @default.
• W2086513675 cites W2151464048 @default.
• W2086513675 cites W2163599835 @default.
• W2086513675 cites W2166002518 @default.
• W2086513675 cites W2169738526 @default.
• W2086513675 cites W2175849508 @default.
• W2086513675 cites W2346861477 @default.
• W2086513675 cites W4237781946 @default.
• W2086513675 doi "https://doi.org/10.1016/j.bbrc.2003.10.078" @default.
• W2086513675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14623263" @default.
• W2086513675 hasPublicationYear "2003" @default.
• W2086513675 type Work @default.
• W2086513675 sameAs 2086513675 @default.
• W2086513675 citedByCount "59" @default.
• W2086513675 countsByYear W20865136752012 @default.
• W2086513675 countsByYear W20865136752013 @default.
• W2086513675 countsByYear W20865136752014 @default.
• W2086513675 countsByYear W20865136752015 @default.
• W2086513675 countsByYear W20865136752017 @default.
• W2086513675 countsByYear W20865136752018 @default.
• W2086513675 countsByYear W20865136752020 @default.
• W2086513675 countsByYear W20865136752023 @default.
• W2086513675 crossrefType "journal-article" @default.
• W2086513675 hasAuthorship W2086513675A5018955901 @default.
• W2086513675 hasAuthorship W2086513675A5035804617 @default.
• W2086513675 hasAuthorship W2086513675A5037332134 @default.
• W2086513675 hasAuthorship W2086513675A5043144221 @default.
• W2086513675 hasAuthorship W2086513675A5046388572 @default.
• W2086513675 hasAuthorship W2086513675A5052070829 @default.
• W2086513675 hasAuthorship W2086513675A5059173679 @default.
• W2086513675 hasConcept C104317684 @default.
• W2086513675 hasConcept C121912465 @default.
• W2086513675 hasConcept C140173407 @default.
• W2086513675 hasConcept C143948831 @default.
• W2086513675 hasConcept C148738053 @default.
• W2086513675 hasConcept C150194340 @default.
• W2086513675 hasConcept C153911025 @default.
• W2086513675 hasConcept C154253233 @default.
• W2086513675 hasConcept C190727270 @default.
• W2086513675 hasConcept C20875687 @default.
• W2086513675 hasConcept C33288867 @default.
• W2086513675 hasConcept C41091548 @default.
• W2086513675 hasConcept C54355233 @default.
• W2086513675 hasConcept C552990157 @default.
• W2086513675 hasConcept C86803240 @default.
• W2086513675 hasConceptScore W2086513675C104317684 @default.
• W2086513675 hasConceptScore W2086513675C121912465 @default.
• W2086513675 hasConceptScore W2086513675C140173407 @default.
• W2086513675 hasConceptScore W2086513675C143948831 @default.
• W2086513675 hasConceptScore W2086513675C148738053 @default.
• W2086513675 hasConceptScore W2086513675C150194340 @default.
• W2086513675 hasConceptScore W2086513675C153911025 @default.
• W2086513675 hasConceptScore W2086513675C154253233 @default.
• W2086513675 hasConceptScore W2086513675C190727270 @default.
• W2086513675 hasConceptScore W2086513675C20875687 @default.
• W2086513675 hasConceptScore W2086513675C33288867 @default.
• W2086513675 hasConceptScore W2086513675C41091548 @default.
• W2086513675 hasConceptScore W2086513675C54355233 @default.
• W2086513675 hasConceptScore W2086513675C552990157 @default.
• W2086513675 hasConceptScore W2086513675C86803240 @default.

• next