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- W2086523714 abstract "Tremendous insight into the molecular and genetic pathogenesis of cerebral cavernous malformations (CCMs) has been gained over the past 2 decades. This includes the identification of 3 distinct genes involved in familial CCMs. Still, a number of unanswered questions regarding the process from gene mutation to vascular malformation remain. It is becoming more evident that the disruption of interendothelial junctions and ensuing vascular hyperpermeability play a principal role. The purpose of this review is to summarize the current understanding of CCM genes, associated proteins, and functional pathways. Promising molecular and genetic therapies targeted at identified molecular aberrations are discussed as well." @default.
- W2086523714 created "2016-06-24" @default.
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- W2086523714 creator A5050082012 @default.
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- W2086523714 date "2010-09-01" @default.
- W2086523714 modified "2023-09-26" @default.
- W2086523714 title "Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution" @default.
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- W2086523714 doi "https://doi.org/10.3171/2010.5.focus10121" @default.
- W2086523714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6599630" @default.
- W2086523714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20809762" @default.
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