Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086524624> ?p ?o ?g. }
- W2086524624 endingPage "158" @default.
- W2086524624 startingPage "151" @default.
- W2086524624 abstract "Leukemic cell apoptosis may be enhanced by appropriate oxidative stress. We report here the mechanism of Jurkat cell apoptosis by monochloramine (NH(2)Cl), a neutrophil-derived oxidant. NH(2)Cl induced caspase-dependent apoptosis, which was preceded by cytochrome c and Smac/Diablo release from mitochondria. Within 10min of NH(2)Cl treatment, c-Jun N-terminal kinase (JNK) activation and elevation of cytosolic Ca(2+) were observed. JNK inhibitors (SP600125 or JNK inhibitor VIII) significantly suppressed the apoptosis as well as caspase cleavage and cytochrome c release. In contrast, Ca(2+) chelation by EGTA+acetoxymethyl-EGTA had no effects on apoptosis. Our results indicated that JNK activation contributed most importantly to the NH(2)Cl-induced apoptosis." @default.
- W2086524624 created "2016-06-24" @default.
- W2086524624 creator A5008868788 @default.
- W2086524624 creator A5017563166 @default.
- W2086524624 creator A5018726876 @default.
- W2086524624 creator A5019210234 @default.
- W2086524624 creator A5037343253 @default.
- W2086524624 creator A5038978246 @default.
- W2086524624 date "2009-01-01" @default.
- W2086524624 modified "2023-10-09" @default.
- W2086524624 title "Activation of c-Jun N-terminal kinase is essential for oxidative stress-induced Jurkat cell apoptosis by monochloramine" @default.
- W2086524624 cites W1506642042 @default.
- W2086524624 cites W1527449265 @default.
- W2086524624 cites W153349786 @default.
- W2086524624 cites W1586360287 @default.
- W2086524624 cites W1964571614 @default.
- W2086524624 cites W1966122833 @default.
- W2086524624 cites W1978259246 @default.
- W2086524624 cites W1980805290 @default.
- W2086524624 cites W1987153373 @default.
- W2086524624 cites W1990752073 @default.
- W2086524624 cites W1995741673 @default.
- W2086524624 cites W2018571781 @default.
- W2086524624 cites W2018978380 @default.
- W2086524624 cites W2020778076 @default.
- W2086524624 cites W2032580133 @default.
- W2086524624 cites W2042409437 @default.
- W2086524624 cites W2054311839 @default.
- W2086524624 cites W2056150470 @default.
- W2086524624 cites W2062853648 @default.
- W2086524624 cites W2063702713 @default.
- W2086524624 cites W2065294001 @default.
- W2086524624 cites W2070044720 @default.
- W2086524624 cites W2072884289 @default.
- W2086524624 cites W2074911197 @default.
- W2086524624 cites W2081690888 @default.
- W2086524624 cites W2092678097 @default.
- W2086524624 cites W2093675973 @default.
- W2086524624 cites W2096931514 @default.
- W2086524624 cites W2099524003 @default.
- W2086524624 cites W2110029891 @default.
- W2086524624 cites W2114111268 @default.
- W2086524624 cites W2116635868 @default.
- W2086524624 cites W2117170204 @default.
- W2086524624 cites W2122057254 @default.
- W2086524624 cites W2127586352 @default.
- W2086524624 cites W2132001873 @default.
- W2086524624 cites W2137912423 @default.
- W2086524624 cites W2140329514 @default.
- W2086524624 cites W2160345685 @default.
- W2086524624 cites W2162628305 @default.
- W2086524624 cites W2162653594 @default.
- W2086524624 cites W2165997736 @default.
- W2086524624 cites W2416893432 @default.
- W2086524624 cites W989016558 @default.
- W2086524624 doi "https://doi.org/10.1016/j.leukres.2008.07.009" @default.
- W2086524624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18718660" @default.
- W2086524624 hasPublicationYear "2009" @default.
- W2086524624 type Work @default.
- W2086524624 sameAs 2086524624 @default.
- W2086524624 citedByCount "17" @default.
- W2086524624 countsByYear W20865246242012 @default.
- W2086524624 countsByYear W20865246242013 @default.
- W2086524624 countsByYear W20865246242014 @default.
- W2086524624 countsByYear W20865246242015 @default.
- W2086524624 countsByYear W20865246242018 @default.
- W2086524624 countsByYear W20865246242022 @default.
- W2086524624 crossrefType "journal-article" @default.
- W2086524624 hasAuthorship W2086524624A5008868788 @default.
- W2086524624 hasAuthorship W2086524624A5017563166 @default.
- W2086524624 hasAuthorship W2086524624A5018726876 @default.
- W2086524624 hasAuthorship W2086524624A5019210234 @default.
- W2086524624 hasAuthorship W2086524624A5037343253 @default.
- W2086524624 hasAuthorship W2086524624A5038978246 @default.
- W2086524624 hasConcept C153911025 @default.
- W2086524624 hasConcept C178790620 @default.
- W2086524624 hasConcept C179464577 @default.
- W2086524624 hasConcept C181199279 @default.
- W2086524624 hasConcept C184235292 @default.
- W2086524624 hasConcept C185592680 @default.
- W2086524624 hasConcept C190283241 @default.
- W2086524624 hasConcept C203014093 @default.
- W2086524624 hasConcept C2776090121 @default.
- W2086524624 hasConcept C2776151105 @default.
- W2086524624 hasConcept C2777658833 @default.
- W2086524624 hasConcept C28859421 @default.
- W2086524624 hasConcept C29311851 @default.
- W2086524624 hasConcept C31573885 @default.
- W2086524624 hasConcept C48349386 @default.
- W2086524624 hasConcept C519063684 @default.
- W2086524624 hasConcept C55493867 @default.
- W2086524624 hasConcept C86803240 @default.
- W2086524624 hasConcept C8891405 @default.
- W2086524624 hasConcept C95444343 @default.
- W2086524624 hasConcept C98424977 @default.
- W2086524624 hasConcept C98539663 @default.
- W2086524624 hasConceptScore W2086524624C153911025 @default.
- W2086524624 hasConceptScore W2086524624C178790620 @default.