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- W2086526738 abstract "Extracellular field recordings were made in CA1 in the hippocampal explant cultures in oxygenated artificial cerebrospinal fluid. Schaffer collaterals were stimulated with 1-s trains of 60 Hz pulses every 10 min. Seizures were reliably elicited with progressive lengthening over 1-2 h. D-APV, an N-methyl-D-aspartate (NMDA) antagonist, stereoselectively blocked the development of seizures. Thus we have demonstrated that in vitro epileptogenesis occurs in hippocampal explant cultures through NMDA receptor mediated mechanisms." @default.
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- W2086526738 date "1992-08-01" @default.
- W2086526738 modified "2023-10-18" @default.
- W2086526738 title "NMDA-receptor mediated electrical epileptogenesis in the organotypic culture of rat hippocampus" @default.
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- W2086526738 doi "https://doi.org/10.1016/0006-8993(92)91171-a" @default.
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