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• W2086534626 abstract "Elucidation of the molecular mechanisms by which 5‑fluorouracil (5‑FU) induces apoptosis is required in order to understand the resistance of colorectal cancer (CRC) cells to 5‑FU. In the current study, 5‑FU‑induced apoptosis was assessed using the propidium iodide method. Involvement of protein kinase C (PKC) was assessed by evaluating the extent of their activation in CRC, following treatment with 5‑FU, using biochemical inhibitors and western blot analysis. The results revealed that 5‑FU induces varying degrees of apoptosis in CRC cells; HCT116 cells were identified to be the most sensitive cells and SW480 were the least sensitive. In addition, 5‑FU‑induced apoptosis was caspase‑dependent as it appeared to be initiated by caspase‑9. Furthermore, PKCε was marginally expressed in CRC cells and no changes were observed in the levels of cleavage or phosphorylation following treatment with 5‑FU. The treatment of HCT116 cells with 5‑FU increased the expression, phosphorylation and cleavage of PKCδ. The inhibition of PKCδ was found to significantly inhibit 5‑FU‑induced apoptosis. These results indicated that 5‑FU induces apoptosis in CRC by the activation of PKCδ and caspase‑9. In addition, the levels of PKCδ activation may determine the sensitivity of CRC to 5‑FU." @default.
• W2086534626 created "2016-06-24" @default.
• W2086534626 creator A5039604144 @default.
• W2086534626 creator A5072739312 @default.
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• W2086534626 date "2014-06-02" @default.
• W2086534626 modified "2023-10-05" @default.
• W2086534626 title "5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-δ" @default.
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• W2086534626 doi "https://doi.org/10.3892/ol.2014.2211" @default.
• W2086534626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4081407" @default.
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• W2086534626 hasPublicationYear "2014" @default.
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