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• W2086534778 abstract "The mitogen-activated protein kinase (MAPK) pathway is a highly conserved signaling cascade that converts extracellular signals into various outputs. In Caenorhabditis elegans, asymmetric expression of the candidate odorant receptor STR-2 in either the left or the right of two bilaterally symmetrical olfactory AWC neurons is regulated by axon contact and Ca2+ signaling. We show that the MAPK kinase (MAPKK) SEK-1 is required for asymmetric expression in AWC neurons. Genetic and biochemical analyses reveal that SEK-1 functions in a pathway downstream of UNC-43 and NSY-1, Ca2+/calmodulin-dependent protein kinase II (CaMKII) and MAPK kinase kinase (MAPKKK), respectively. Thus, the NSY-1-SEK-1-MAPK cascade is activated by Ca2+ signaling through CaMKII and establishes asymmetric cell fate decision during neuronal development." @default.
• W2086534778 created "2016-06-24" @default.
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• W2086534778 date "2002-01-01" @default.
• W2086534778 modified "2023-10-16" @default.
• W2086534778 title "SEK‐1 MAPKK mediates Ca ²⁺ signaling to determine neuronal asymmetric development in <i>Caenorhabditis elegans</i>" @default.
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• W2086534778 doi "https://doi.org/10.1093/embo-reports/kvf001" @default.
• W2086534778 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1083920" @default.
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