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• W2086537746 abstract "OBJECTIVES: To assess the tolerability and efficacy of high-dose (25–30 mg/kg per day) ursodeoxycholic acid (UDCA) in patients with primary sclerosing cholangitis (PSC). METHODS: Thirty patients with PSC were enrolled in this pilot study and treated for 1 yr. Changes in the Mayo risk score at 1 yr of treatment and projected survival at 4 yr were compared with that observed in patients randomized to placebo (n = 52) or UDCA (n = 53) at a dose of 13–15 mg/kg per day. RESULTS: A marked improvement in serum alkaline phosphatase activity (1265 ± 172 vs 693 ± 110 U/L, p < 0.001), AST (161 ± 037 vs 77 ± 13 U/L, p = 0.001), albumin (4.0 ± 0.1 vs 4.2 ± 0.1 g/dl, p = 0.03), and total bilirubin (1.6 ± 0.3 vs 1.3 ± 0.2 mg/dl, p = 0.1) occurred at 1 yr of therapy with high-dose UDCA. Changes in the Mayo risk score after 1 yr of treatment were significantly different among the three groups (p < 0.001), and these changes would be translated into a significantly different expected survival at 4 yr (p = 0.05). This expected survival at 4 yr was significantly different between placebo and the dose of 25–30 mg/kg per day (p = 0.04), but not between placebo and the dose of 13–15 mg/kg per day (p = 0.4). High-dose UDCA was well tolerated. CONCLUSIONS: UDCA at a dose of 25–30 mg/kg per day may be of benefit for patients with PSC, and this regimen deserves further evaluation in a long-term, randomized, placebo-controlled trial." @default.
• W2086537746 created "2016-06-24" @default.
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• W2086537746 date "2001-05-01" @default.
• W2086537746 modified "2023-10-18" @default.
• W2086537746 title "High-Dose Ursodeoxycholic Acid as a Therapy for Patients With Primary Sclerosing Cholangitis" @default.
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• W2086537746 doi "https://doi.org/10.1111/j.1572-0241.2001.03777.x" @default.
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