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• W2086544280 startingPage "699" @default.
• W2086544280 abstract "Large-scale clinical studies have indicated that angiotensin receptor blockers (ARBs) have beneficial effects against cardiovascular diseases. We designed this study to compare the effects of an ARB and a calcium channel blocker (CCB) on coronary flow velocity reserve (CFVR), a predictor of cardiovascular events, as estimated using transthoracic Doppler echocardiography. Sixteen hypertensive patients (63.1±9.6 years old; 10 males) were randomly allocated in a double-blind fashion to valsartan (n=8, 40–80 mg/day) or nifedipine (n=8, 20–40 mg/day) groups. Age- and gender-matched subjects without hypertension were enrolled as a control group (n=12). CFVR was calculated by dividing the adenosine triphosphate–induced hyperemic flow velocity by the basal flow velocity in the left anterior descending coronary artery. Baseline characteristics and reduction in systolic and diastolic blood pressure after 6 months were similar in both groups. CFVR in the valsartan group increased from 2.34±0.38 to 3.10±0.84 at 2 months (p<0.05), and to 3.04±1.09 at 6 months (p<0.01). Both values became comparable to that in the control group (2.81±0.60). CFVR in the valsartan group was significantly higher (p<0.001) than that in the nifedipine group, which was little changed at 6 months. This discrepancy was derived from the significant increase of hyperemic velocity in the valsartan group, from 36.6±17.3 cm/s to 41.1±12.7 cm/s at 2 months, and to 48.1±20.2 cm/s at 6 months. We concluded that the ARB valsartan not only reduced high blood pressure but improved CFVR in hypertensive patients. However, these effects were not seen with the CCB nifedipine." @default.
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• W2086544280 date "2007-01-01" @default.
• W2086544280 modified "2023-10-12" @default.
• W2086544280 title "Angiotensin Receptor Blocker Improves Coronary Flow Velocity Reserve in Hypertensive Patients: Comparison with Calcium Channel Blocker" @default.
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• W2086544280 doi "https://doi.org/10.1291/hypres.30.699" @default.
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