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• W2086557280 startingPage "71" @default.
• W2086557280 abstract "Huperzine A (HupA), isolated from Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase. It has been found to reverse or attenuate cognitive deficits in a broad range of animal models. Clinical trials in China have demonstrated that HupA significantly relieves memory deficits in aged subjects, patients with benign senescent forgetfulness, Alzheimer’s disease (AD) and vascular dementia (VD), with minimal peripheral cholinergic side effects compared with other AChEIs in use. HupA possesses the ability to protect cells against hydrogen peroxide, β-amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53 and caspase-3, protect mitochondria, and interfere with APP metabolism. Antagonizing effects on NMDA receptors and potassium currents may contribute to the neuroprotection as well. It is also possible that the non-catalytic function of AChE is involved in neuroprotective effects of HupA. The therapeutic effects of HupA on AD or VD are probably exerted via a multi-target mechanism." @default.
• W2086557280 created "2016-06-24" @default.
• W2086557280 creator A5030309864 @default.
• W2086557280 creator A5070812231 @default.
• W2086557280 date "2005-01-01" @default.
• W2086557280 modified "2023-10-18" @default.
• W2086557280 title "Neuroprotective Effects of Huperzine A" @default.
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• W2086557280 cites W1941863248 @default.
• W2086557280 cites W1970926091 @default.
• W2086557280 cites W1971922123 @default.
• W2086557280 cites W1976540989 @default.
• W2086557280 cites W1977908516 @default.
• W2086557280 cites W1977949594 @default.
• W2086557280 cites W1979406476 @default.
• W2086557280 cites W1982528995 @default.
• W2086557280 cites W1987469323 @default.
• W2086557280 cites W1990543766 @default.
• W2086557280 cites W1992795123 @default.
• W2086557280 cites W1994067502 @default.
• W2086557280 cites W1995957068 @default.
• W2086557280 cites W2003526387 @default.
• W2086557280 cites W2004713321 @default.
• W2086557280 cites W2005546962 @default.
• W2086557280 cites W2006904109 @default.
• W2086557280 cites W2007514801 @default.
• W2086557280 cites W2010666191 @default.
• W2086557280 cites W2011621207 @default.
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• W2086557280 cites W2041026703 @default.
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• W2086557280 doi "https://doi.org/10.1159/000085387" @default.
• W2086557280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15956816" @default.
• W2086557280 hasPublicationYear "2005" @default.
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