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• W2086577046 abstract "In this study, we developed an in-line methodology that combines analytical with pharmacological techniques to characterize metabolites of human histamine H4 receptor (hH4R) ligands. Liquid chromatographic separation of metabolic mixtures is coupled to high-resolution fractionation into 96- or 384-well plates and directly followed by a cell-based reporter gene assay to measure receptor signaling. The complete methodology was designed, optimized, validated, and ultimately miniaturized into a high-density well plate format. Finally, the methodology was demonstrated in a metabolic profiling setting for three hH4R lead compounds and the drug clozapine. This new methodology comprises integrated analytical separations, mass spectrometry, and a cell-based signal transduction–driven reporter gene assay that enables the implementation of comprehensive metabolic profiling earlier in the drug discovery process." @default.
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• W2086577046 date "2012-12-01" @default.
• W2086577046 modified "2023-10-06" @default.
• W2086577046 title "Development of a Profiling Strategy for Metabolic Mixtures by Combining Chromatography and Mass Spectrometry with Cell-Based GPCR Signaling" @default.
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• W2086577046 doi "https://doi.org/10.1177/1087057112451922" @default.
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