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- W2086584376 abstract "Abstract Morphological transformation in C3H/10T 1 2 cells treated with varied concentrations of benzo (α) pyrene (BP) was measured following subculture at low cell densities. Subconfluent cultures exposed to BP were allowed to grow to confluence, trypsinized, and reseeded at cell densities ranging from 5 to 2,300 surviving cells/cm 2 . These secondary cultures were incubated for 8 to 9 weeks, stained, and examined for evidence of morphological transformation. BP-treated cells reseeded in virtual isolation in microwells (approx. 5 surviving cells/cm 2 ) transformed at frequencies up to 14.5%. At these low initial cell densities, transformation frequency did not demonstrate a significant dependence on BP concentration. However, BP-treated cells reseeded at higher densities (11 to 2,300 surviving cells/cm 2 ) showed both density-dependent transformation frequencies and BP-concentration dependence of transformation. As reported previously (Haber et al., Cancer Res. 37 1644, 1977), the subculturing of treated cells did not affect the BP-concentration dependence of focus formation in the C3H/10T 1 2 transformation assay. Cell density-dependent suppression of morphological transformation has now been observed over a wide range of BP concentration. We suggest that this phenomenon is associated with colony interactions and consider various possible mechanisms of BP involvement." @default.
- W2086584376 created "2016-06-24" @default.
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- W2086584376 date "1978-05-01" @default.
- W2086584376 modified "2023-09-25" @default.
- W2086584376 title "Morphological transformation of cells subcultured at low cell densities" @default.
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- W2086584376 doi "https://doi.org/10.1016/0024-3205(78)90063-2" @default.
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