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- W2086586523 abstract "Background Haptocorrin (HC) carries cobalamin analogues (CorA), but whether CorA are produced in the body is unknown. All cobalamins (Cbl) to the foetus are delivered by the Cbl-specific protein transcobalamin (TC), and therefore analysis of cord serum for CorA may help to clarify the origin of CorA. Methods HC-CorA were quantified in paired samples of cord serum from newborns and serum from mothers (n = 69). Results The CorA-concentration was higher in cord serum (median = 380, range: 41–780 pmol/L) than in serum from the mothers (median = 160, range: 64–330 pmol/L), (p<0.0001). HPLC-analysis showed CorA-peaks with retention times of 13.5, 14,5 and 16.5 min in samples from both the mother and cord serum. The peak with retention time 16.5 min constituted 24% (mother) and 45% (cord serum) of the total amount CorA, and eluted as does dicyanocobinamide. Conclusion Our results support that CorA in the human body are derived from Cbl." @default.
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- W2086586523 date "2013-04-09" @default.
- W2086586523 modified "2023-10-05" @default.
- W2086586523 title "Cobalamin Analogues in Humans: A Study on Maternal and Cord Blood" @default.
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- W2086586523 doi "https://doi.org/10.1371/journal.pone.0061194" @default.
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