FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086586613> ?p ?o ?g. }

• W2086586613 endingPage "696" @default.
• W2086586613 startingPage "688" @default.
• W2086586613 abstract "The aim of the present study was to examine nitric oxide (NO)-mediated coronary vascular responses in a mouse model of obesity and diabetes induced by a high-fat, high-carbohydrate diet. We hypothesized that endogenous NO bioavailability would be reduced in obese/diabetic mouse hearts due to enhanced superoxide anion production, and that coronary smooth muscle responses to exogenous NO would be reduced.Age-matched, male C57BL/6J mice were fed either a control diet or a high-fat, high-carbohydrate diet. After 15 weeks, the mice were anesthetized and their hearts were removed and perfused by the Langendorff method under constant flow conditions with an oxygenated buffer solution, and changes in coronary vascular resistance were quantified.Mice fed the high-fat, high-carbohydrate diet became obese, hyperglycaemic and hyperinsulinaemic. Coronary vasoconstrictor responses to NO synthase inhibition by N(omega)-nitro-L-arginine methyl ester were reduced in obese/diabetic mice; normal responses were restored by pretreatment with the superoxide dismutase mimetic 2,2,6,6-tetramethyl-1-piperidinyloxy (Tempol). Coronary endothelium-independent vasodilation to the NO donor (+/-)-S-nitroso-N-acetylpenicillamine (SNAP) was reduced; however, 8-bromo-cyclic guanosine monophosphate (cGMP)-induced vasodilation was unchanged in obese/diabetic hearts.These findings suggest that in a diet-induced mouse model of obesity and diabetes, NO bioavailability is reduced by increased superoxide NO scavenging leading to impaired NO-mediated vasodilation. Furthermore, the attenuation of SNAP-induced vasodilation may be due to increased reactive oxygen species scavenging of exogenous NO because normal vascular smooth muscle NO signalling is maintained as indicated by similar 8-bromo-cGMP responses in control and obese/diabetic hearts." @default.
• W2086586613 created "2016-06-24" @default.
• W2086586613 creator A5022556747 @default.
• W2086586613 creator A5040096421 @default.
• W2086586613 creator A5046910270 @default.
• W2086586613 creator A5086320275 @default.
• W2086586613 date "2006-09-08" @default.
• W2086586613 modified "2023-10-10" @default.
• W2086586613 title "Diet-induced obesity and diabetes reduce coronary responses to nitric oxide due to reduced bioavailability in isolated mouse hearts" @default.
• W2086586613 cites W1890261708 @default.
• W2086586613 cites W1968485895 @default.
• W2086586613 cites W1970728146 @default.
• W2086586613 cites W1970737985 @default.
• W2086586613 cites W1986303821 @default.
• W2086586613 cites W1991061419 @default.
• W2086586613 cites W1993387626 @default.
• W2086586613 cites W1994294460 @default.
• W2086586613 cites W2005126581 @default.
• W2086586613 cites W2005469488 @default.
• W2086586613 cites W2007406273 @default.
• W2086586613 cites W2010686273 @default.
• W2086586613 cites W2020267609 @default.
• W2086586613 cites W2021857191 @default.
• W2086586613 cites W2023629942 @default.
• W2086586613 cites W2024790801 @default.
• W2086586613 cites W2029891724 @default.
• W2086586613 cites W2032272012 @default.
• W2086586613 cites W2033359234 @default.
• W2086586613 cites W2037331996 @default.
• W2086586613 cites W2038464101 @default.
• W2086586613 cites W2040802598 @default.
• W2086586613 cites W2051806208 @default.
• W2086586613 cites W2064880478 @default.
• W2086586613 cites W2096281503 @default.
• W2086586613 cites W2101835986 @default.
• W2086586613 cites W2105061132 @default.
• W2086586613 cites W2109964559 @default.
• W2086586613 cites W2111400229 @default.
• W2086586613 cites W2111707471 @default.
• W2086586613 cites W2117155692 @default.
• W2086586613 cites W2128389658 @default.
• W2086586613 cites W2131890454 @default.
• W2086586613 cites W2145490597 @default.
• W2086586613 cites W2150442739 @default.
• W2086586613 cites W2151002896 @default.
• W2086586613 cites W2154067087 @default.
• W2086586613 cites W2154388708 @default.
• W2086586613 cites W2154759462 @default.
• W2086586613 cites W2273250957 @default.
• W2086586613 cites W2332422194 @default.
• W2086586613 cites W2428602706 @default.
• W2086586613 doi "https://doi.org/10.1111/j.1463-1326.2006.00650.x" @default.
• W2086586613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17697061" @default.
• W2086586613 hasPublicationYear "2006" @default.
• W2086586613 type Work @default.
• W2086586613 sameAs 2086586613 @default.
• W2086586613 citedByCount "40" @default.
• W2086586613 countsByYear W20865866132012 @default.
• W2086586613 countsByYear W20865866132013 @default.
• W2086586613 countsByYear W20865866132014 @default.
• W2086586613 countsByYear W20865866132015 @default.
• W2086586613 countsByYear W20865866132016 @default.
• W2086586613 countsByYear W20865866132017 @default.
• W2086586613 countsByYear W20865866132018 @default.
• W2086586613 countsByYear W20865866132019 @default.
• W2086586613 countsByYear W20865866132020 @default.
• W2086586613 countsByYear W20865866132021 @default.
• W2086586613 countsByYear W20865866132022 @default.
• W2086586613 countsByYear W20865866132023 @default.
• W2086586613 crossrefType "journal-article" @default.
• W2086586613 hasAuthorship W2086586613A5022556747 @default.
• W2086586613 hasAuthorship W2086586613A5040096421 @default.
• W2086586613 hasAuthorship W2086586613A5046910270 @default.
• W2086586613 hasAuthorship W2086586613A5086320275 @default.
• W2086586613 hasConcept C120770815 @default.
• W2086586613 hasConcept C126322002 @default.
• W2086586613 hasConcept C134018914 @default.
• W2086586613 hasConcept C181199279 @default.
• W2086586613 hasConcept C181389837 @default.
• W2086586613 hasConcept C185592680 @default.
• W2086586613 hasConcept C2779395532 @default.
• W2086586613 hasConcept C2780795997 @default.
• W2086586613 hasConcept C2780994212 @default.
• W2086586613 hasConcept C2992686903 @default.
• W2086586613 hasConcept C519581460 @default.
• W2086586613 hasConcept C55493867 @default.
• W2086586613 hasConcept C555293320 @default.
• W2086586613 hasConcept C71924100 @default.
• W2086586613 hasConcept C98274493 @default.
• W2086586613 hasConceptScore W2086586613C120770815 @default.
• W2086586613 hasConceptScore W2086586613C126322002 @default.
• W2086586613 hasConceptScore W2086586613C134018914 @default.
• W2086586613 hasConceptScore W2086586613C181199279 @default.
• W2086586613 hasConceptScore W2086586613C181389837 @default.
• W2086586613 hasConceptScore W2086586613C185592680 @default.
• W2086586613 hasConceptScore W2086586613C2779395532 @default.
• W2086586613 hasConceptScore W2086586613C2780795997 @default.
• W2086586613 hasConceptScore W2086586613C2780994212 @default.

• next