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• W2086593306 abstract "Background The retinal determination (RD) network is an evolutionarily conserved regulatory circuit that governs early events in the development of eyes throughout the animal kingdom. Ectopic expression of many members of this network leads to the transformation of non-retinal epithelia into eye tissue. An often-overlooked observation is that only particular cell-populations within a handful of tissues are capable of having their primary developmental instructions superseded and overruled. Methodology/Preliminary Findings Here we confirm that indeed, only a discrete number of cell populations within the imaginal discs that give rise to the head, antenna, legs, wings and halteres have the cellular plasticity to have their developmental fates altered. In contrast to previous reports, we find that all transformable cell populations do not lie within the TGFβ or Hedgehog signaling domains. Additionally neither signaling cascade alone is sufficient for non-retinal cell types to be converted into retinal tissue. The transformation “hot spots” that we have identified appear to coincide with several previously defined transdetermination “weak spots”, suggesting that ectopic eye formation is less the result of one network overriding the orders of another, as previously thought, but rather is the physical manifestation of redirecting cell populations of enormous cellular plasticity. We also demonstrate that the initiation of eye formation in non-retinal tissues occurs asynchronously compared to that of the normal eye suggesting that retinal development is not under the control of a global developmental clock. Conclusions/Significance We conclude that the subregions of non-retinal tissues that are capable of supporting eye formation represent specialized cell-populations that have a different level of plasticity than other cells within these tissues and may be the founder cells of each tissue." @default.
• W2086593306 created "2016-06-24" @default.
• W2086593306 creator A5023797946 @default.
• W2086593306 creator A5062541904 @default.
• W2086593306 date "2010-01-07" @default.
• W2086593306 modified "2023-09-27" @default.
• W2086593306 title "Identification of Retinal Transformation Hot Spots in Developing Drosophila Epithelia" @default.
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• W2086593306 doi "https://doi.org/10.1371/journal.pone.0008510" @default.
• W2086593306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2799516" @default.
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