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- W2086597371 abstract "This paper reports an improved catalytic molecular beacon. Addition of the target oligonucleotide activates a DNA enzyme (DNAzyme), which, in turn, activates multiple copies of molecular beacons (MB) and gives rise to a strong fluorescence signal. In a previous design, the activated DNAzyme could oligomerize, especially dimerize, and result in inactivation of the DNAzyme. The current design avoids this problem, upon activated by the target DNA, the DNAzyme will stay constantly active. With the improved method, a detection of 10 pM DNA has been demonstrated, which is 1000 times more sensitive than the method previously reported." @default.
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- W2086597371 date "2005-09-15" @default.
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- W2086597371 title "DNAzyme amplification of molecular beacon signal" @default.
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- W2086597371 doi "https://doi.org/10.1016/j.talanta.2005.06.044" @default.
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