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• W2086610719 abstract "Optimization of a lead thiazole amide MF-152 led to the identification of potent bicyclic heteroaryl SCD1 inhibitors with good mouse pharmacokinetic profiles. In a view to target the liver for efficacy and to avoid SCD1 inhibition in the skin and eyes where adverse effects were previously observed in rodents, representative systemically-distributed SCD1 inhibitors were converted into liver-targeting SCD1 inhibitors." @default.
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• W2086610719 date "2011-10-01" @default.
• W2086610719 modified "2023-09-27" @default.
• W2086610719 title "Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors" @default.
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• W2086610719 doi "https://doi.org/10.1016/j.bmcl.2011.08.037" @default.
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