FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086635082> ?p ?o ?g. }

• W2086635082 endingPage "803" @default.
• W2086635082 startingPage "791" @default.
• W2086635082 abstract "Interaction between CD2 and its counterreceptor, CD58 (LFA-3), on opposing cells optimizes immune recognition, facilitating contacts between helper T lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. Here, we report the crystal structure of the heterophilic adhesion complex between the amino-terminal domains of human CD2 and CD58. A strikingly asymmetric, orthogonal, face-to-face interaction involving the major beta sheets of the respective immunoglobulin-like domains with poor shape complementarity is revealed. In the virtual absence of hydrophobic forces, interdigitating charged amino acid side chains form hydrogen bonds and salt links at the interface (approximately 1200 A2), imparting a high degree of specificity albeit with low affinity (K(D) of approximately microM). These features explain CD2-CD58 dynamic binding, offering insights into interactions of related immunoglobulin superfamily receptors." @default.
• W2086635082 created "2016-06-24" @default.
• W2086635082 creator A5006030795 @default.
• W2086635082 creator A5010274753 @default.
• W2086635082 creator A5013709830 @default.
• W2086635082 creator A5022231208 @default.
• W2086635082 creator A5023335726 @default.
• W2086635082 creator A5039755388 @default.
• W2086635082 creator A5054084032 @default.
• W2086635082 creator A5090569228 @default.
• W2086635082 date "1999-06-01" @default.
• W2086635082 modified "2023-10-15" @default.
• W2086635082 title "Structure of a Heterophilic Adhesion Complex between the Human CD2 and CD58 (LFA-3) Counterreceptors" @default.
• W2086635082 cites W1502632447 @default.
• W2086635082 cites W1505981109 @default.
• W2086635082 cites W1539796472 @default.
• W2086635082 cites W1548757996 @default.
• W2086635082 cites W1555214742 @default.
• W2086635082 cites W1562441478 @default.
• W2086635082 cites W1563409320 @default.
• W2086635082 cites W1599880469 @default.
• W2086635082 cites W1608855442 @default.
• W2086635082 cites W1612909786 @default.
• W2086635082 cites W1620801087 @default.
• W2086635082 cites W1864506204 @default.
• W2086635082 cites W1966286149 @default.
• W2086635082 cites W1966669891 @default.
• W2086635082 cites W1966951979 @default.
• W2086635082 cites W1977201389 @default.
• W2086635082 cites W1977523366 @default.
• W2086635082 cites W1979841260 @default.
• W2086635082 cites W1982327997 @default.
• W2086635082 cites W1983383412 @default.
• W2086635082 cites W1984770583 @default.
• W2086635082 cites W1985524929 @default.
• W2086635082 cites W1986856281 @default.
• W2086635082 cites W1988090285 @default.
• W2086635082 cites W1988719059 @default.
• W2086635082 cites W1989978944 @default.
• W2086635082 cites W2000772846 @default.
• W2086635082 cites W2000980755 @default.
• W2086635082 cites W2008708467 @default.
• W2086635082 cites W2015064119 @default.
• W2086635082 cites W2016620180 @default.
• W2086635082 cites W2019286212 @default.
• W2086635082 cites W2020455973 @default.
• W2086635082 cites W2020644789 @default.
• W2086635082 cites W2023430158 @default.
• W2086635082 cites W2028231353 @default.
• W2086635082 cites W2031772330 @default.
• W2086635082 cites W2035323213 @default.
• W2086635082 cites W2037910920 @default.
• W2086635082 cites W2041452459 @default.
• W2086635082 cites W2041673942 @default.
• W2086635082 cites W2043531999 @default.
• W2086635082 cites W2047357490 @default.
• W2086635082 cites W2049090751 @default.
• W2086635082 cites W2049521571 @default.
• W2086635082 cites W2050809403 @default.
• W2086635082 cites W2052636519 @default.
• W2086635082 cites W2054403251 @default.
• W2086635082 cites W2056034415 @default.
• W2086635082 cites W2058404844 @default.
• W2086635082 cites W2065270456 @default.
• W2086635082 cites W2067353129 @default.
• W2086635082 cites W2067495948 @default.
• W2086635082 cites W2069911462 @default.
• W2086635082 cites W2074306237 @default.
• W2086635082 cites W2075770210 @default.
• W2086635082 cites W2076978886 @default.
• W2086635082 cites W2080476827 @default.
• W2086635082 cites W2080997655 @default.
• W2086635082 cites W2086195958 @default.
• W2086635082 cites W2086518221 @default.
• W2086635082 cites W2088689097 @default.
• W2086635082 cites W2089714150 @default.
• W2086635082 cites W2092017901 @default.
• W2086635082 cites W2093001188 @default.
• W2086635082 cites W2094799089 @default.
• W2086635082 cites W2096810938 @default.
• W2086635082 cites W2100694556 @default.
• W2086635082 cites W2106315897 @default.
• W2086635082 cites W2107976817 @default.
• W2086635082 cites W2116517185 @default.
• W2086635082 cites W2135945715 @default.
• W2086635082 cites W2136867383 @default.
• W2086635082 cites W2140799426 @default.
• W2086635082 cites W2141109151 @default.
• W2086635082 cites W2145306211 @default.
• W2086635082 cites W2150368859 @default.
• W2086635082 cites W2155454007 @default.
• W2086635082 cites W2155740919 @default.
• W2086635082 cites W2157417177 @default.
• W2086635082 cites W2174557896 @default.
• W2086635082 cites W4246353614 @default.
• W2086635082 doi "https://doi.org/10.1016/s0092-8674(00)80790-4" @default.
• W2086635082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10380930" @default.
• W2086635082 hasPublicationYear "1999" @default.

• next