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- W2086643604 abstract "PURPOSE: To evaluate whether functional and metabolic changes recover after aortic valve replacement (AVR). MATERIALS AND METHODS: Eighteen men with aortic valve stenosis (mean pressure gradient ± SD, 79.9 mm Hg ± 15.1) underwent magnetic resonance (MR) imaging and phosphorus 31 MR spectroscopy. In nine patients who underwent AVR, MR imaging and spectroscopy were repeated 40 weeks ± 12 after AVR. Ten age-matched healthy men were control subjects. RESULTS: Before AVR, the myocardial phosphocreatine (PCr)-to–adenosine triphosphate (ATP) ratio in the 18 patients was 1.24 ± 0.17 and 1.43 ± 0.14 in the control group (P < .01). In nine patients who underwent follow-up MR spectroscopy, the ratio increased from 1.28 ± 0.17 to 1.47 ± 0.14 (P < .05) following AVR. Before AVR, early acceleration peak corrected for cardiac output was (0.043 ± 0.008) × 10−3 sec−1 in patients and (0.081 ± 0.033) × 10−3 sec−1 in the control group (P < .05). After 40 weeks ± 12, the mean early acceleration peak corrected for cardiac output in the nine patients increased significantly to (0.055 ± 0.006) × 10−3 sec−1 (P < .05), although it was still significantly lower than that of the control group (P < .05). Before AVR, a significant correlation was found between the myocardial PCr-ATP ratio and left ventricular diastolic function (n = 18; P < .05). CONCLUSION: Severe aortic valve stenosis leads to a decreased myocardial PCr-ATP ratio and impairment of left ventricular diastolic function; following AVR, the ratio normalizes completely, whereas function improves significantly. There is an association between altered myocardial high-energy phosphate metabolism and impaired left ventricular diastolic function." @default.
- W2086643604 created "2016-06-24" @default.
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- W2086643604 date "2001-06-01" @default.
- W2086643604 modified "2023-10-14" @default.
- W2086643604 title "Aortic Valve Replacement in Patients with Aortic Valve Stenosis Improves Myocardial Metabolism and Diastolic Function" @default.
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- W2086643604 doi "https://doi.org/10.1148/radiology.219.3.r01jn25637" @default.
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