SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086646687> ?p ?o ?g. }

Showing items 1 to 100 of ±107 with 100 items per page.

W2086646687 endingPage "2082" @default.
W2086646687 startingPage "2075" @default.
W2086646687 abstract "We used a mouse model of acute respiratory infections to investigate the role of Toll-like receptor 2 (TLR2) and TLR4 in the host response to Haemophilus influenzae. Acute aerosol exposures to wild-type strains of H. influenzae showed that TLR4 function was essential for TNF-alpha induction, neutrophil influx, and bacterial clearance. To determine how lipooligosaccharide (LOS) modifications would affect the role of TLR4 in inducing the host response, we used acute infections with an H. influenzae strain expressing a mutation in the htrB gene. This mutant strain expresses an LOS subunit with decreased acylation. In response to H. influenzae htrB infection, tumor necrosis factor alpha (TNF-alpha) secretion remained TLR4 dependent. But the decrease in LOS acylation made the neutrophil influx and the bacterial clearance also dependent on TLR2, as shown by the decreased host response elicited in TLR2 knockout mice compared to C57BL/6 mice. A subsequent analysis of TLR2 and TLR4 gene expression by quantitative PCR indicated that TLR4 function induces TLR2 expression and vice versa. These results indicate that some changes in the LOS subunit of H. influenzae can favor signaling through non-TLR4 receptors, such as TLR2. The results also indicate a close interaction between TLR4 and TLR2 that tightly regulates the expression of both receptors." @default.
W2086646687 created "2016-06-24" @default.
W2086646687 creator A5001909008 @default.
W2086646687 creator A5020863829 @default.
W2086646687 creator A5032356336 @default.
W2086646687 creator A5036414419 @default.
W2086646687 date "2005-04-01" @default.
W2086646687 modified "2023-09-25" @default.
W2086646687 title "Differential Involvement of Toll-Like Receptors 2 and 4 in the Host Response to Acute Respiratory Infections with Wild-Type and Mutant <i>Haemophilus influenzae</i> Strains" @default.
W2086646687 cites W1480290224 @default.
W2086646687 cites W1489852543 @default.
W2086646687 cites W1531148794 @default.
W2086646687 cites W1615858282 @default.
W2086646687 cites W1646413467 @default.
W2086646687 cites W1656495682 @default.
W2086646687 cites W1978926805 @default.
W2086646687 cites W1993513102 @default.
W2086646687 cites W2014638089 @default.
W2086646687 cites W2015143975 @default.
W2086646687 cites W2016862474 @default.
W2086646687 cites W2024904486 @default.
W2086646687 cites W2057809738 @default.
W2086646687 cites W2090110893 @default.
W2086646687 cites W2099065204 @default.
W2086646687 cites W2107928905 @default.
W2086646687 cites W2111017750 @default.
W2086646687 cites W2111025555 @default.
W2086646687 cites W2111345022 @default.
W2086646687 cites W2113534668 @default.
W2086646687 cites W2119435062 @default.
W2086646687 cites W2135720956 @default.
W2086646687 cites W2139829222 @default.
W2086646687 cites W2149611550 @default.
W2086646687 cites W2152326627 @default.
W2086646687 cites W2157672700 @default.
W2086646687 cites W2159613168 @default.
W2086646687 cites W2163590666 @default.
W2086646687 cites W2167059596 @default.
W2086646687 cites W2282103272 @default.
W2086646687 cites W2325356462 @default.
W2086646687 cites W4234317413 @default.
W2086646687 doi "https://doi.org/10.1128/iai.73.4.2075-2082.2005" @default.
W2086646687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1087404" @default.
W2086646687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15784548" @default.
W2086646687 hasPublicationYear "2005" @default.
W2086646687 type Work @default.
W2086646687 sameAs 2086646687 @default.
W2086646687 citedByCount "35" @default.
W2086646687 countsByYear W20866466872012 @default.
W2086646687 countsByYear W20866466872013 @default.
W2086646687 countsByYear W20866466872015 @default.
W2086646687 countsByYear W20866466872017 @default.
W2086646687 countsByYear W20866466872021 @default.
W2086646687 crossrefType "journal-article" @default.
W2086646687 hasAuthorship W2086646687A5001909008 @default.
W2086646687 hasAuthorship W2086646687A5020863829 @default.
W2086646687 hasAuthorship W2086646687A5032356336 @default.
W2086646687 hasAuthorship W2086646687A5036414419 @default.
W2086646687 hasBestOaLocation W20866466871 @default.
W2086646687 hasConcept C136449434 @default.
W2086646687 hasConcept C170493617 @default.
W2086646687 hasConcept C17991360 @default.
W2086646687 hasConcept C203014093 @default.
W2086646687 hasConcept C2776070231 @default.
W2086646687 hasConcept C2776709828 @default.
W2086646687 hasConcept C2776925733 @default.
W2086646687 hasConcept C2781236682 @default.
W2086646687 hasConcept C501593827 @default.
W2086646687 hasConcept C55493867 @default.
W2086646687 hasConcept C86803240 @default.
W2086646687 hasConcept C89423630 @default.
W2086646687 hasConceptScore W2086646687C136449434 @default.
W2086646687 hasConceptScore W2086646687C170493617 @default.
W2086646687 hasConceptScore W2086646687C17991360 @default.
W2086646687 hasConceptScore W2086646687C203014093 @default.
W2086646687 hasConceptScore W2086646687C2776070231 @default.
W2086646687 hasConceptScore W2086646687C2776709828 @default.
W2086646687 hasConceptScore W2086646687C2776925733 @default.
W2086646687 hasConceptScore W2086646687C2781236682 @default.
W2086646687 hasConceptScore W2086646687C501593827 @default.
W2086646687 hasConceptScore W2086646687C55493867 @default.
W2086646687 hasConceptScore W2086646687C86803240 @default.
W2086646687 hasConceptScore W2086646687C89423630 @default.
W2086646687 hasIssue "4" @default.
W2086646687 hasLocation W20866466871 @default.
W2086646687 hasLocation W20866466872 @default.
W2086646687 hasLocation W20866466873 @default.
W2086646687 hasLocation W20866466874 @default.
W2086646687 hasOpenAccess W2086646687 @default.
W2086646687 hasPrimaryLocation W20866466871 @default.
W2086646687 hasRelatedWork W1897355343 @default.
W2086646687 hasRelatedWork W1914689199 @default.
W2086646687 hasRelatedWork W1993663150 @default.
W2086646687 hasRelatedWork W2029376832 @default.
W2086646687 hasRelatedWork W2033318041 @default.
W2086646687 hasRelatedWork W2047730062 @default.
W2086646687 hasRelatedWork W2086646687 @default.
W2086646687 hasRelatedWork W2159613168 @default.