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• W2086647500 abstract "The pituitary gonadotropin follicle stimulating hormone (FSH) interacts with its membrane-bound receptor, to produce biologic effects. Traditional functions of FSH include, follicular development and estradiol production in females and the regulation of Sertoli cell action and spermatogenesis in males. FSHbeta knock-out mice and transgenic mice, serve as models for FSH deficiency and excess, respectively. In addition, mutations of both FSHbeta and FSHR genes have been characterized in humans, although phenotypic effects of the ligand appear to be more profound than those of its receptor. FSH is essential for normal puberty and fertility in females, particularly ovarian follicular development beyond the antral stage. In males, FSH is necessary for normal spermatogenesis and when FSH function is completely absent, infertility occurs. With partial FSH deficiency in males, spermatogenesis is affected, but fertility may still be possible. FSH may also be necessary for normal androgen synthesis in males and females." @default.
• W2086647500 created "2016-06-24" @default.
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• W2086647500 date "2000-03-01" @default.
• W2086647500 modified "2023-09-25" @default.
• W2086647500 title "Mutations of follicle stimulating hormone-β and its receptor in human and mouse: genotype/phenotype" @default.
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• W2086647500 doi "https://doi.org/10.1016/s0303-7207(99)00217-8" @default.
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