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• W2086652024 endingPage "486" @default.
• W2086652024 startingPage "477" @default.
• W2086652024 abstract "From the consideration of general features of the anticodon loop and stem in tRNA and the properties of present-day translation, we put forward a plausible scenario to explain the evolution of the genetic code from a highly ambiguous triplet code to the present refined decoding system. Our model based on the reading of the code suggests that the anticodon of primordial tRNA could adopt either the 3′ or the 5′ stacked conformation permitting the formation of the “best two out of three” base pairs, either the first and second codon position or the second and third.Progressive acquisition of precise structural constraint and the modification of bases in the anticodon loop would give way eventually to the less ambiguous “two out of three” reading mechanism having only the 3′ stacked conformation. Further adjustments of base composition and modification leads inevitably to the present generalized code. In this way the primordial code encoding 4–8 amino acids or related derivates evolves smoothly to the present code having 20 amino acids." @default.
• W2086652024 created "2016-06-24" @default.
• W2086652024 creator A5067449994 @default.
• W2086652024 creator A5071801811 @default.
• W2086652024 date "1973-05-01" @default.
• W2086652024 modified "2023-10-14" @default.
• W2086652024 title "The distribution of modified nucleosides in transfer RNAs" @default.
• W2086652024 cites W100133296 @default.
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• W2086652024 doi "https://doi.org/10.1016/0022-5193(73)90112-4" @default.
• W2086652024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4728730" @default.
• W2086652024 hasPublicationYear "1973" @default.
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