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• W2086672904 abstract "An improved understanding of the characteristics of proinsulin and its intermediate conversion products has resulted from the use of novel assays for distinguishing these molecules from insulin. Use of such assays may help clarify the role of insulin deficiency in non-insulin-dependent diabetes mellitus (NIDDM). Levels of proinsulinlike molecules are elevated in subjects who have NIDDM or impaired glucose tolerance. However, the observation that hyperproinsulinemia may occur in individuals without hyperglycemia suggests that elevated proinsulin levels may be a manifestation of β-cell dysfunction rather than of increased demand on the β cell. Although the metabolic effects of proinsulinlike molecules have yet to be elucidated, some studies indicate that the effect of these molecules on hepatocytes is greater than that on other insulin-sensitive cells. A potential therapeutic role of proinsulin in NIDDM thus has been envisioned, in that suppression of hepatic glucose output might reduce the risk of hypoglycemia caused by increased peripheral glucose uptake. Clinical study of proinsulin has been discontinued, however, owing to the finding of an association between use of human proinsulin and cardiovascular adverse events in one study. In NIDDM subjects, associations have been reported between elevated des 31,32 proinsulin concentrations and such cardiovascular risk factors as elevated blood pressure, increased serum triglyceride and total cholesterol values, and elevated plasminogen-activator inhibitor levels, suggesting a role of proinsulin in cardiovascular risk. Epidemiologic data, however, indicate that elevated levels of proinsulinlike molecules are related to low birth weight and that low birth weight is associated with increased risk of cardiovascular events, suggesting that inadequate intrauterine nutrition may be the common antecedent of augmented proinsulin levels and cardiovascular risk." @default.
• W2086672904 created "2016-06-24" @default.
• W2086672904 creator A5049262011 @default.
• W2086672904 date "1993-04-01" @default.
• W2086672904 modified "2023-09-27" @default.
• W2086672904 title "Circulating proinsulinlike molecules" @default.
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• W2086672904 doi "https://doi.org/10.1016/1056-8727(93)90036-x" @default.
• W2086672904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8518453" @default.
• W2086672904 hasPublicationYear "1993" @default.
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