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• W2086685655 endingPage "634" @default.
• W2086685655 startingPage "619" @default.
• W2086685655 abstract "There is considerable interest in the potential impact of several polyunsaturated fatty acids (PUFAs) in mitigating the significant morbidity and mortality caused by degenerative diseases of the cardiovascular system and brain. Despite this interest, confusion surrounds the extent of conversion in humans of the parent PUFA, linoleic acid or α-linolenic acid (ALA), to their respective long-chain PUFA products. As a result, there is uncertainty about the potential benefits of ALA versus eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Some of the confusion arises because although mammals have the necessary enzymes to make the long-chain PUFA from the parent PUFA, in vivo studies in humans show that ≈5% of ALA is converted to EPA and <0.5% of ALA is converted to DHA. Because the capacity of this pathway is very low in healthy, nonvegetarian humans, even large amounts of dietary ALA have a negligible effect on plasma DHA, an effect paralleled in the ω6 PUFA by a negligible effect of dietary linoleic acid on plasma arachidonic acid. Despite this inefficient conversion, there are potential roles in human health for ALA and EPA that could be independent of their metabolism to DHA through the desaturation – chain elongation pathway." @default.
• W2086685655 created "2016-06-24" @default.
• W2086685655 creator A5067321423 @default.
• W2086685655 creator A5088681787 @default.
• W2086685655 date "2007-08-01" @default.
• W2086685655 modified "2023-10-11" @default.
• W2086685655 title "Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements" @default.
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