FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086687958> ?p ?o ?g. }

• W2086687958 endingPage "33" @default.
• W2086687958 startingPage "26" @default.
• W2086687958 abstract "Oestrogen actions within the hypothalamus are essential for a range of reproductive functions. In this study, we sought to develop a method for suppressing central oestrogen action without affecting peripheral oestrogenic effects. We administered the oestrogen receptor antagonist ICI-182,780 (ICI) via crystalline implants into the left lateral ventricle or the arcuate nucleus and measured the effectiveness of this drug on three endpoints known to be regulated by oestrogen: gonadotrophin-releasing hormone (GnRH) pulse frequency, progesterone receptor expression and the generation of a sustained prolactin surge during late pregnancy. To confirm that central ICI administration had no effect on peripheral actions of oestrogen, we monitored changes in uterine weight. Intracerebroventricular ICI treatment reversed the inhibitory effects of oestrogen on GnRH pulse frequency, as measured by plasma luteinising hormone pulse frequency. No effect on the oestrogenic induction of progesterone receptors within the arcuate nucleus or ventromedial hypothalamus was observed; however, a small yet significant reduction in progesterone receptor expression within dopaminergic neurones in the arcuate nucleus was observed. Intracerebroventricular or direct crystalline ICI administration to the arcuate nucleus did not change the serum prolactin level during late pregnancy. Central administration of ICI did not affect uterine weight, and thus did not have a peripheral effect. These data suggest that central administration of ICI can overcome some actions of oestrogen in the brain, such as GnRH pulse frequency, but does not affect other oestrogen mediated actions, including the induction of progesterone receptors or the antepartum prolactin surge. Thus, it appears that there is a differential sensitivity to the inhibition of central oestrogen actions by ICI." @default.
• W2086687958 created "2016-06-24" @default.
• W2086687958 creator A5013110682 @default.
• W2086687958 creator A5024992893 @default.
• W2086687958 creator A5038700827 @default.
• W2086687958 date "2007-01-01" @default.
• W2086687958 modified "2023-09-24" @default.
• W2086687958 title "Differential Effects of Centrally-Administered Oestrogen Antagonist ICI-182,780 on Oestrogen-Sensitive Functions in the Hypothalamus" @default.
• W2086687958 cites W1821147188 @default.
• W2086687958 cites W183344562 @default.
• W2086687958 cites W1969955122 @default.
• W2086687958 cites W1983753462 @default.
• W2086687958 cites W1986851103 @default.
• W2086687958 cites W1988262291 @default.
• W2086687958 cites W2016468210 @default.
• W2086687958 cites W2037925394 @default.
• W2086687958 cites W2039258787 @default.
• W2086687958 cites W2052555027 @default.
• W2086687958 cites W2052757541 @default.
• W2086687958 cites W2054521012 @default.
• W2086687958 cites W2065888308 @default.
• W2086687958 cites W2069530524 @default.
• W2086687958 cites W2070146132 @default.
• W2086687958 cites W2079841863 @default.
• W2086687958 cites W2081138280 @default.
• W2086687958 cites W2084135368 @default.
• W2086687958 cites W2090754786 @default.
• W2086687958 cites W2093187048 @default.
• W2086687958 cites W2097069565 @default.
• W2086687958 cites W2113103296 @default.
• W2086687958 cites W2114220190 @default.
• W2086687958 cites W2117639343 @default.
• W2086687958 cites W2127624529 @default.
• W2086687958 cites W2130244428 @default.
• W2086687958 cites W2147673480 @default.
• W2086687958 cites W2161623422 @default.
• W2086687958 cites W2169457085 @default.
• W2086687958 cites W2170728568 @default.
• W2086687958 cites W2285229821 @default.
• W2086687958 cites W2305627972 @default.
• W2086687958 cites W300795297 @default.
• W2086687958 cites W4212936275 @default.
• W2086687958 cites W4234232959 @default.
• W2086687958 cites W4238276666 @default.
• W2086687958 cites W4247968364 @default.
• W2086687958 cites W4248738771 @default.
• W2086687958 cites W4249842623 @default.
• W2086687958 cites W4250600423 @default.
• W2086687958 cites W4251018402 @default.
• W2086687958 doi "https://doi.org/10.1111/j.1365-2826.2006.01499.x" @default.
• W2086687958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17184483" @default.
• W2086687958 hasPublicationYear "2007" @default.
• W2086687958 type Work @default.
• W2086687958 sameAs 2086687958 @default.
• W2086687958 citedByCount "17" @default.
• W2086687958 countsByYear W20866879582012 @default.
• W2086687958 countsByYear W20866879582013 @default.
• W2086687958 countsByYear W20866879582015 @default.
• W2086687958 countsByYear W20866879582018 @default.
• W2086687958 countsByYear W20866879582022 @default.
• W2086687958 crossrefType "journal-article" @default.
• W2086687958 hasAuthorship W2086687958A5013110682 @default.
• W2086687958 hasAuthorship W2086687958A5024992893 @default.
• W2086687958 hasAuthorship W2086687958A5038700827 @default.
• W2086687958 hasConcept C126322002 @default.
• W2086687958 hasConcept C134018914 @default.
• W2086687958 hasConcept C137183658 @default.
• W2086687958 hasConcept C170493617 @default.
• W2086687958 hasConcept C2777003273 @default.
• W2086687958 hasConcept C2778458369 @default.
• W2086687958 hasConcept C2779064019 @default.
• W2086687958 hasConcept C513476851 @default.
• W2086687958 hasConcept C71315377 @default.
• W2086687958 hasConcept C71924100 @default.
• W2086687958 hasConcept C86803240 @default.
• W2086687958 hasConceptScore W2086687958C126322002 @default.
• W2086687958 hasConceptScore W2086687958C134018914 @default.
• W2086687958 hasConceptScore W2086687958C137183658 @default.
• W2086687958 hasConceptScore W2086687958C170493617 @default.
• W2086687958 hasConceptScore W2086687958C2777003273 @default.
• W2086687958 hasConceptScore W2086687958C2778458369 @default.
• W2086687958 hasConceptScore W2086687958C2779064019 @default.
• W2086687958 hasConceptScore W2086687958C513476851 @default.
• W2086687958 hasConceptScore W2086687958C71315377 @default.
• W2086687958 hasConceptScore W2086687958C71924100 @default.
• W2086687958 hasConceptScore W2086687958C86803240 @default.
• W2086687958 hasIssue "1" @default.
• W2086687958 hasLocation W20866879581 @default.
• W2086687958 hasLocation W20866879582 @default.
• W2086687958 hasOpenAccess W2086687958 @default.
• W2086687958 hasPrimaryLocation W20866879581 @default.
• W2086687958 hasRelatedWork W1983836497 @default.
• W2086687958 hasRelatedWork W1984327601 @default.
• W2086687958 hasRelatedWork W2014813016 @default.
• W2086687958 hasRelatedWork W2033668374 @default.
• W2086687958 hasRelatedWork W2040682267 @default.
• W2086687958 hasRelatedWork W2054867132 @default.
• W2086687958 hasRelatedWork W2062579683 @default.

• next