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• W2086692116 abstract "S,S'-[disulfanediylbis(dialkylaminopropane-2,1-diyl)]bis- (dialkylaminothiocarbamate) (14-31) were prepared and evaluated for the spermicidal activity and antifungal activity. Dialkyldithiocarbamates (1-5) were reacted with epichlorohydrin to give 1-dialkylaminocarbothioic acid S-[(2,3-epithio)propyl]ester (7-11), these on further reaction with a secondary amine gave S,S'-[disulfanediylbis(dialkylaminopropane-2,1-diyl)]bis- (dialkylaminothiocarbamate) (14-31). Some of these compounds (16, 19-21, 23, 30, 31) were found to be very potent spermicidal agents with marginal antifungal activity. Two compounds (20, 21) were 25 times more active than nonoxynol-9 (N-9), the spermicide currently in the market." @default.
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• W2086692116 date "2007-11-01" @default.
• W2086692116 modified "2023-10-16" @default.
• W2086692116 title "Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents" @default.
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• W2086692116 doi "https://doi.org/10.1016/j.bmc.2007.08.024" @default.
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