Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086700213> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2086700213 endingPage "715" @default.
- W2086700213 startingPage "707" @default.
- W2086700213 abstract "We sought to determine whether changes in the expression of early response genes ( GADD153 , p21 and c‐ Jun ) are indicators of chemotherapy response in gastric cancer. Three human gastric cancer cell lines were exposed to 5‐fluorouracil or cisplatin in vitro . Xenografts of TMK‐1 cells in nude mice were also treated with 5‐fluorouracil or cisplatin in vivo . For each of these treatments, we tested for a correlation between early gene expression levels and inhibition ratios derived at a later time. A 5‐fluorouracil derivative, S‐1, and cisplatin were administered to 12 patients with advanced gastric cancer for 3 weeks. Gene expression levels were measured using biopsy specimens obtained by endoscopy soon after initiation of chemotherapy. There was a significant correlation between expression levels of these genes at 24 h and inhibition ratios at 72 h in vitro . Cut‐off values determined from receiver‐operating characteristic curves were 1.3 for GADD153 , 1.8 for p21 and 2.1 for c‐ Jun There was also a significant correlation between gene expression levels at 2 days and inhibition ratios at 21 days in vivo . Cut‐off values were 1.8 for GADD153 , 1.9 for p21 and 2.2 for c‐ Jun . Levels of early response gene expression in patients showing progressive disease were significantly lower than those in patients with partial response. Changes in the expression of the three early response genes soon after drug administration could improve predictions of the final outcome of chemotherapy in gastric cancer. ( Cancer Sci 2007; 98: 707–715)" @default.
- W2086700213 created "2016-06-24" @default.
- W2086700213 creator A5004925989 @default.
- W2086700213 creator A5018112691 @default.
- W2086700213 creator A5020608796 @default.
- W2086700213 creator A5027285655 @default.
- W2086700213 creator A5043888002 @default.
- W2086700213 creator A5045197572 @default.
- W2086700213 creator A5048945082 @default.
- W2086700213 creator A5078489994 @default.
- W2086700213 creator A5079517184 @default.
- W2086700213 date "2007-03-09" @default.
- W2086700213 modified "2023-09-29" @default.
- W2086700213 title "Predictive value of GADD153, p21 and c-Jun for chemotherapy response in gastric cancer" @default.
- W2086700213 cites W1850446337 @default.
- W2086700213 cites W1966945476 @default.
- W2086700213 cites W1972155103 @default.
- W2086700213 cites W1989751695 @default.
- W2086700213 cites W2020824048 @default.
- W2086700213 cites W2027678619 @default.
- W2086700213 cites W2027768657 @default.
- W2086700213 cites W2066312401 @default.
- W2086700213 cites W2077902459 @default.
- W2086700213 cites W2093966537 @default.
- W2086700213 cites W2114918609 @default.
- W2086700213 cites W2116893774 @default.
- W2086700213 cites W2129241106 @default.
- W2086700213 cites W4239514162 @default.
- W2086700213 doi "https://doi.org/10.1111/j.1349-7006.2007.00435.x" @default.
- W2086700213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17355264" @default.
- W2086700213 hasPublicationYear "2007" @default.
- W2086700213 type Work @default.
- W2086700213 sameAs 2086700213 @default.
- W2086700213 citedByCount "12" @default.
- W2086700213 countsByYear W20867002132012 @default.
- W2086700213 countsByYear W20867002132013 @default.
- W2086700213 countsByYear W20867002132015 @default.
- W2086700213 crossrefType "journal-article" @default.
- W2086700213 hasAuthorship W2086700213A5004925989 @default.
- W2086700213 hasAuthorship W2086700213A5018112691 @default.
- W2086700213 hasAuthorship W2086700213A5020608796 @default.
- W2086700213 hasAuthorship W2086700213A5027285655 @default.
- W2086700213 hasAuthorship W2086700213A5043888002 @default.
- W2086700213 hasAuthorship W2086700213A5045197572 @default.
- W2086700213 hasAuthorship W2086700213A5048945082 @default.
- W2086700213 hasAuthorship W2086700213A5078489994 @default.
- W2086700213 hasAuthorship W2086700213A5079517184 @default.
- W2086700213 hasConcept C104317684 @default.
- W2086700213 hasConcept C121608353 @default.
- W2086700213 hasConcept C126322002 @default.
- W2086700213 hasConcept C142724271 @default.
- W2086700213 hasConcept C143998085 @default.
- W2086700213 hasConcept C150194340 @default.
- W2086700213 hasConcept C207001950 @default.
- W2086700213 hasConcept C2775934546 @default.
- W2086700213 hasConcept C2776694085 @default.
- W2086700213 hasConcept C2778239845 @default.
- W2086700213 hasConcept C2780456651 @default.
- W2086700213 hasConcept C502942594 @default.
- W2086700213 hasConcept C54355233 @default.
- W2086700213 hasConcept C71924100 @default.
- W2086700213 hasConcept C86803240 @default.
- W2086700213 hasConceptScore W2086700213C104317684 @default.
- W2086700213 hasConceptScore W2086700213C121608353 @default.
- W2086700213 hasConceptScore W2086700213C126322002 @default.
- W2086700213 hasConceptScore W2086700213C142724271 @default.
- W2086700213 hasConceptScore W2086700213C143998085 @default.
- W2086700213 hasConceptScore W2086700213C150194340 @default.
- W2086700213 hasConceptScore W2086700213C207001950 @default.
- W2086700213 hasConceptScore W2086700213C2775934546 @default.
- W2086700213 hasConceptScore W2086700213C2776694085 @default.
- W2086700213 hasConceptScore W2086700213C2778239845 @default.
- W2086700213 hasConceptScore W2086700213C2780456651 @default.
- W2086700213 hasConceptScore W2086700213C502942594 @default.
- W2086700213 hasConceptScore W2086700213C54355233 @default.
- W2086700213 hasConceptScore W2086700213C71924100 @default.
- W2086700213 hasConceptScore W2086700213C86803240 @default.
- W2086700213 hasIssue "5" @default.
- W2086700213 hasLocation W20867002131 @default.
- W2086700213 hasLocation W20867002132 @default.
- W2086700213 hasOpenAccess W2086700213 @default.
- W2086700213 hasPrimaryLocation W20867002131 @default.
- W2086700213 hasRelatedWork W13394025 @default.
- W2086700213 hasRelatedWork W2187491254 @default.
- W2086700213 hasRelatedWork W2363409655 @default.
- W2086700213 hasRelatedWork W2394853503 @default.
- W2086700213 hasRelatedWork W2406263212 @default.
- W2086700213 hasRelatedWork W2409439767 @default.
- W2086700213 hasRelatedWork W2414573978 @default.
- W2086700213 hasRelatedWork W363598932 @default.
- W2086700213 hasRelatedWork W4206600817 @default.
- W2086700213 hasRelatedWork W4249729814 @default.
- W2086700213 hasVolume "98" @default.
- W2086700213 isParatext "false" @default.
- W2086700213 isRetracted "false" @default.
- W2086700213 magId "2086700213" @default.
- W2086700213 workType "article" @default.