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• W2086701001 abstract "The budding and fission of vesicles during membrane trafficking requires many proteins, including those that coat the vesicles, adaptor proteins that recruit components of the coat, and small GTPases that initiate vesicle formation. In addition, vesicle formation in vitro is promoted by the hydrolysis of acyl-CoA lipid esters. The mechanisms by which these lipid esters are directed to the appropriate membranes in vivo, and their precise roles in vesicle biogenesis, are not yet understood. Here, we present the first report on membrane associated ACBP domain-containing protein-1 (MAA-1), a novel membrane-associated member of the acyl-CoA–binding protein family. We show that in Caenorhabditis elegans, MAA-1 localizes to intracellular membrane organelles in the secretory and endocytic pathway and that mutations in maa-1 reduce the rate of endosomal recycling. A lack of maa-1 activity causes a change in endosomal morphology. Although in wild type, many endosomal organelles have long tubular protrusions, loss of MAA-1 activity results in loss of the tubular domains, suggesting the maa-1 is required for the generation or maintenance of these domains. Furthermore, we demonstrate that MAA-1 binds fatty acyl-CoA in vitro and that this ligand-binding ability is important for its function in vivo. Our results are consistent with a role for MAA-1 in an acyl-CoA–dependent process during vesicle formation." @default.
• W2086701001 created "2016-06-24" @default.
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• W2086701001 date "2006-10-01" @default.
• W2086701001 modified "2023-10-17" @default.
• W2086701001 title "MAA-1, a Novel Acyl-CoA–binding Protein Involved in Endosomal Vesicle Transport in<i>Caenorhabditis elegans</i>" @default.
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• W2086701001 doi "https://doi.org/10.1091/mbc.e06-01-0035" @default.
• W2086701001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1635345" @default.
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