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• W2086702012 abstract "Abstract Background NDRG 2 (N-Myc downstream-regulated gene 2) was initially cloned in our laboratory. Previous results have shown that NDRG 2 expressed differentially in normal and cancer tissues. Specifically, NDRG 2 mRNA was down-regulated or undetectable in several human cancers, and over-expression of NDRG 2 inhibited the proliferation of cancer cells. NDRG 2 also exerts important functions in cell differentiation and tumor suppression. However, it remains unclear whether NDRG 2 participates in carcinogenesis of the thyroid. Methods In this study, we investigated the expression profile of human NDRG 2 in thyroid adenomas and carcinomas, by examining tissues from individuals with thyroid adenomas (n = 40) and carcinomas (n = 35), along with corresponding normal tissues. Immunohistochemistry, quantitative RT-PCR and western blot methods were utilized to determine both the protein and mRNA expression status of Ndrg2 and c-Myc. Results The immunostaining analysis revealed a decrease of Ndrg2 expression in thyroid carcinomas. When comparing adenomas or carcinomas with adjacent normal tissue from the same individual, the mRNA expression level of NDRG 2 was significantly decreased in thyroid carcinoma tissues, while there was little difference in adenoma tissues. This differential expression was confirmed at the protein level by western blotting. However, there were no significant correlations of NDRG 2 expression with gender, age, different histotypes of thyroid cancers or distant metastases. Conclusion Our data indicates that NDRG 2 may participate in thyroid carcinogenesis. This finding provides novel insight into the important role of NDRG2 in the development of thyroid carcinomas. Future studies are needed to address whether the down-regulation of NDRG 2 is a cause or a consequence of the progression from a normal thyroid to a carcinoma." @default.
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• W2086702012 date "2008-10-22" @default.
• W2086702012 modified "2023-10-02" @default.
• W2086702012 title "Reduced expression of N-Myc downstream-regulated gene 2 in human thyroid cancer" @default.
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• W2086702012 doi "https://doi.org/10.1186/1471-2407-8-303" @default.
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