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- W2086707947 abstract "The recent discovery that RNA can act as a catalyst, apart from carrying genetic information, has given a new dimension to the field of gene therapy and has come to act synergistically with antisense technology. Ribozymes can be used to down-regulate (by RNA cleavage) or repair (by RNA trans-splicing) unwanted gene expression involved in disease. Hammerhead ribozymes have been used extensively to down-regulate gene expression in many diseases such as viral infections and cancer. Group I intron ribozymes on the other hand, have only been tried to repair inherited mutations but hold great promise for the future. Peptide nucleic acids (PNAs) technology is another new technology, which is currently been tried to block gene or RNA function. Gene therapy protocols need significant improvements in order to be used routinely in patients and hopefully, these new players should prove valuable to identifying new therapies for several untreated diseases." @default.
- W2086707947 created "2016-06-24" @default.
- W2086707947 creator A5038837130 @default.
- W2086707947 date "2000-11-15" @default.
- W2086707947 modified "2023-10-03" @default.
- W2086707947 title "Ribozyme and peptide–nucleic acid-based gene therapy" @default.
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- W2086707947 cites W1570375907 @default.
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- W2086707947 cites W1977335029 @default.
- W2086707947 cites W1981814048 @default.
- W2086707947 cites W1985911775 @default.
- W2086707947 cites W1994794104 @default.
- W2086707947 cites W1995540108 @default.
- W2086707947 cites W1997533384 @default.
- W2086707947 cites W1997783712 @default.
- W2086707947 cites W1999545960 @default.
- W2086707947 cites W2003575039 @default.
- W2086707947 cites W2005064067 @default.
- W2086707947 cites W2007613355 @default.
- W2086707947 cites W2010659535 @default.
- W2086707947 cites W2010951888 @default.
- W2086707947 cites W2012508954 @default.
- W2086707947 cites W2013692083 @default.
- W2086707947 cites W2016296831 @default.
- W2086707947 cites W2017033748 @default.
- W2086707947 cites W2019818589 @default.
- W2086707947 cites W2019982212 @default.
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- W2086707947 cites W2027588508 @default.
- W2086707947 cites W2032479241 @default.
- W2086707947 cites W2042841971 @default.
- W2086707947 cites W2044164984 @default.
- W2086707947 cites W2047908387 @default.
- W2086707947 cites W2050992506 @default.
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- W2086707947 cites W2069438067 @default.
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- W2086707947 doi "https://doi.org/10.1016/s0169-409x(00)00088-0" @default.
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