FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086714447> ?p ?o ?g. }

• W2086714447 endingPage "71" @default.
• W2086714447 startingPage "65" @default.
• W2086714447 abstract "<i>Background:</i> The olfactory bulbectomised (OBX) rat model is a chronic model of depression in which behavioural and neuroimmunoendocrine changes are reversed only after chronic antidepressant treatment. The cyclooxygenase 2 (COX-2) inhibitor celecoxib has been shown to improve the depressive symptoms in patients with major depression. <i>Methods:</i> The association between blood and brain immunological and behavioural changes in chronic treatment with COX-2 inhibitor was explored in the OBX rats and their sham-operated controls. <i>Results:</i> The OBX group showed significantly higher locomotor activity than the other groups in the first 5 min in the open field. In the home cage emergence test, the OBX group showed a significantly shorter latency period compared to the sham group (z = –3.192, p = 0.001) but there was no difference between the other three groups. In the hypothalamus, the OBX group had a significantly higher interleukin 1β (IL-1β) concentration than the OBX + celecoxib group (z = –1.89, p = 0.05) as well as a significantly higher IL-10 concentration (z = –1.995, p = 0.046). In the prefrontal cortex, the OBX group showed significantly higher concentrations of tumour necrosis factor α (z = –2.205, p = 0.028) and IL-1β (z = –3.361, p = 0.001) than the OBX + celecoxib group, but a significantly lower concentration of IL-10 (p = –3.361, p = 0.001) than the OBX + celecoxib group. <i>Conclusions:</i> The results of this study supported the potential therapeutic role of the COX-2 inhibitor celecoxib. It is possible that the behavioural changes following the chronic administration of celecoxib to the OBX rats are associated with an attenuation of the increase in the pro-inflammatory cytokines in the brain." @default.
• W2086714447 created "2016-06-24" @default.
• W2086714447 creator A5004432345 @default.
• W2086714447 creator A5029130571 @default.
• W2086714447 creator A5034820560 @default.
• W2086714447 creator A5042385396 @default.
• W2086714447 creator A5072756628 @default.
• W2086714447 creator A5086727096 @default.
• W2086714447 date "2007-01-01" @default.
• W2086714447 modified "2023-09-27" @default.
• W2086714447 title "Effect of the COX-2 Inhibitor Celecoxib on Behavioural and Immune Changes in an Olfactory Bulbectomised Rat Model of Depression" @default.
• W2086714447 cites W1485442945 @default.
• W2086714447 cites W1488753908 @default.
• W2086714447 cites W1512847190 @default.
• W2086714447 cites W1598374636 @default.
• W2086714447 cites W1634190246 @default.
• W2086714447 cites W1883938883 @default.
• W2086714447 cites W1965454331 @default.
• W2086714447 cites W1976770818 @default.
• W2086714447 cites W1990759859 @default.
• W2086714447 cites W1993376226 @default.
• W2086714447 cites W1999721747 @default.
• W2086714447 cites W1999993196 @default.
• W2086714447 cites W2000679986 @default.
• W2086714447 cites W2007043862 @default.
• W2086714447 cites W2013800746 @default.
• W2086714447 cites W2015195658 @default.
• W2086714447 cites W2015371826 @default.
• W2086714447 cites W2016702173 @default.
• W2086714447 cites W2017436597 @default.
• W2086714447 cites W2022462933 @default.
• W2086714447 cites W2025318581 @default.
• W2086714447 cites W2033053214 @default.
• W2086714447 cites W2036052494 @default.
• W2086714447 cites W2041184757 @default.
• W2086714447 cites W2045715094 @default.
• W2086714447 cites W2045900359 @default.
• W2086714447 cites W2049808835 @default.
• W2086714447 cites W2052445727 @default.
• W2086714447 cites W2052970369 @default.
• W2086714447 cites W2055258442 @default.
• W2086714447 cites W2057060667 @default.
• W2086714447 cites W2062929425 @default.
• W2086714447 cites W2067425594 @default.
• W2086714447 cites W2074411049 @default.
• W2086714447 cites W2085680573 @default.
• W2086714447 cites W2085825695 @default.
• W2086714447 cites W2086751676 @default.
• W2086714447 cites W2087376507 @default.
• W2086714447 cites W2087526026 @default.
• W2086714447 cites W2089923844 @default.
• W2086714447 cites W2093539486 @default.
• W2086714447 cites W2094329991 @default.
• W2086714447 cites W2104623394 @default.
• W2086714447 cites W2113605030 @default.
• W2086714447 cites W2146540723 @default.
• W2086714447 cites W2146747402 @default.
• W2086714447 cites W2151041365 @default.
• W2086714447 cites W2168514472 @default.
• W2086714447 cites W2168778445 @default.
• W2086714447 cites W4234193719 @default.
• W2086714447 doi "https://doi.org/10.1159/000107420" @default.
• W2086714447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17713352" @default.
• W2086714447 hasPublicationYear "2007" @default.
• W2086714447 type Work @default.
• W2086714447 sameAs 2086714447 @default.
• W2086714447 citedByCount "96" @default.
• W2086714447 countsByYear W20867144472012 @default.
• W2086714447 countsByYear W20867144472013 @default.
• W2086714447 countsByYear W20867144472014 @default.
• W2086714447 countsByYear W20867144472015 @default.
• W2086714447 countsByYear W20867144472016 @default.
• W2086714447 countsByYear W20867144472017 @default.
• W2086714447 countsByYear W20867144472018 @default.
• W2086714447 countsByYear W20867144472019 @default.
• W2086714447 countsByYear W20867144472020 @default.
• W2086714447 countsByYear W20867144472021 @default.
• W2086714447 countsByYear W20867144472022 @default.
• W2086714447 countsByYear W20867144472023 @default.
• W2086714447 crossrefType "journal-article" @default.
• W2086714447 hasAuthorship W2086714447A5004432345 @default.
• W2086714447 hasAuthorship W2086714447A5029130571 @default.
• W2086714447 hasAuthorship W2086714447A5034820560 @default.
• W2086714447 hasAuthorship W2086714447A5042385396 @default.
• W2086714447 hasAuthorship W2086714447A5072756628 @default.
• W2086714447 hasAuthorship W2086714447A5086727096 @default.
• W2086714447 hasConcept C118552586 @default.
• W2086714447 hasConcept C126322002 @default.
• W2086714447 hasConcept C134018914 @default.
• W2086714447 hasConcept C169900460 @default.
• W2086714447 hasConcept C203014093 @default.
• W2086714447 hasConcept C2776467144 @default.
• W2086714447 hasConcept C2779177272 @default.
• W2086714447 hasConcept C2781161787 @default.
• W2086714447 hasConcept C2781195155 @default.
• W2086714447 hasConcept C71924100 @default.
• W2086714447 hasConcept C8891405 @default.
• W2086714447 hasConceptScore W2086714447C118552586 @default.

• next