Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086714946> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2086714946 endingPage "111" @default.
- W2086714946 startingPage "101" @default.
- W2086714946 abstract "In spontaneously breathing, lightly anesthetized rats with chronically implanted epicortical electrodes, tolerance times were measured from onset of progressive hypoxia, anoxia or decapitation, until ultimate apnea and subsequent cessation of brain electrical activities. Arterial and cerebrovenous blood was collected initially and during progressive hypoxia, starting 5 min after intravenous verapamil or NaCl (controls). Verapamil induced significant hyperpnea, arterial alkalosis, slight bradycardia and brain venous acidosis. During progressive hypoxia, hyperpnea persisted and heart rate remained stable for a longer period than in controls. Tolerance times were significantly prolonged. Time courses of arterial PO2 and PCO2 and of cerebrovenous PO2 were hardly influenced. However, arterial alkalosis and brain venous acidosis became highly significant versus control courses. This raised the O2 saturation in arterial and O2 extraction in cerebral venous blood. Sinus sagittalis puncture needle outflow (as a measure of CBF) tended to be below the control rat courses throughout. This led to a higher O2 supply to the brain in verapamil rats only during severe hypoxia. Verapamil did not prolong tolerance times in anoxia or ischemia. It is concluded that the verapamil-induced increase of tolerance to hypoxia is primarily due to the acid-base (Bohr) effects observed in response to hyperpnea and prolonged cerebral metabolic activity." @default.
- W2086714946 created "2016-06-24" @default.
- W2086714946 creator A5045780837 @default.
- W2086714946 date "1987-01-01" @default.
- W2086714946 modified "2023-09-27" @default.
- W2086714946 title "Verapamil Enhances Brain Function Tolerance against Severe Hypoxia without Enhancing Cerebral Blood Flow in the Rat" @default.
- W2086714946 doi "https://doi.org/10.1159/000138301" @default.
- W2086714946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3114771" @default.
- W2086714946 hasPublicationYear "1987" @default.
- W2086714946 type Work @default.
- W2086714946 sameAs 2086714946 @default.
- W2086714946 citedByCount "3" @default.
- W2086714946 crossrefType "journal-article" @default.
- W2086714946 hasAuthorship W2086714946A5045780837 @default.
- W2086714946 hasConcept C126322002 @default.
- W2086714946 hasConcept C157767197 @default.
- W2086714946 hasConcept C178790620 @default.
- W2086714946 hasConcept C185592680 @default.
- W2086714946 hasConcept C2776777198 @default.
- W2086714946 hasConcept C2777022698 @default.
- W2086714946 hasConcept C2777068682 @default.
- W2086714946 hasConcept C2777449187 @default.
- W2086714946 hasConcept C2777676865 @default.
- W2086714946 hasConcept C2778553927 @default.
- W2086714946 hasConcept C2779246250 @default.
- W2086714946 hasConcept C2779537118 @default.
- W2086714946 hasConcept C2781063116 @default.
- W2086714946 hasConcept C42219234 @default.
- W2086714946 hasConcept C519063684 @default.
- W2086714946 hasConcept C534529494 @default.
- W2086714946 hasConcept C540031477 @default.
- W2086714946 hasConcept C541997718 @default.
- W2086714946 hasConcept C71924100 @default.
- W2086714946 hasConcept C7836513 @default.
- W2086714946 hasConceptScore W2086714946C126322002 @default.
- W2086714946 hasConceptScore W2086714946C157767197 @default.
- W2086714946 hasConceptScore W2086714946C178790620 @default.
- W2086714946 hasConceptScore W2086714946C185592680 @default.
- W2086714946 hasConceptScore W2086714946C2776777198 @default.
- W2086714946 hasConceptScore W2086714946C2777022698 @default.
- W2086714946 hasConceptScore W2086714946C2777068682 @default.
- W2086714946 hasConceptScore W2086714946C2777449187 @default.
- W2086714946 hasConceptScore W2086714946C2777676865 @default.
- W2086714946 hasConceptScore W2086714946C2778553927 @default.
- W2086714946 hasConceptScore W2086714946C2779246250 @default.
- W2086714946 hasConceptScore W2086714946C2779537118 @default.
- W2086714946 hasConceptScore W2086714946C2781063116 @default.
- W2086714946 hasConceptScore W2086714946C42219234 @default.
- W2086714946 hasConceptScore W2086714946C519063684 @default.
- W2086714946 hasConceptScore W2086714946C534529494 @default.
- W2086714946 hasConceptScore W2086714946C540031477 @default.
- W2086714946 hasConceptScore W2086714946C541997718 @default.
- W2086714946 hasConceptScore W2086714946C71924100 @default.
- W2086714946 hasConceptScore W2086714946C7836513 @default.
- W2086714946 hasIssue "2" @default.
- W2086714946 hasLocation W20867149461 @default.
- W2086714946 hasLocation W20867149462 @default.
- W2086714946 hasOpenAccess W2086714946 @default.
- W2086714946 hasPrimaryLocation W20867149461 @default.
- W2086714946 hasRelatedWork W1966423879 @default.
- W2086714946 hasRelatedWork W2046873579 @default.
- W2086714946 hasRelatedWork W2059227122 @default.
- W2086714946 hasRelatedWork W2075118455 @default.
- W2086714946 hasRelatedWork W2086714946 @default.
- W2086714946 hasRelatedWork W2171239909 @default.
- W2086714946 hasRelatedWork W2295738242 @default.
- W2086714946 hasRelatedWork W2435854801 @default.
- W2086714946 hasRelatedWork W4211229847 @default.
- W2086714946 hasRelatedWork W4360601311 @default.
- W2086714946 hasVolume "35" @default.
- W2086714946 isParatext "false" @default.
- W2086714946 isRetracted "false" @default.
- W2086714946 magId "2086714946" @default.
- W2086714946 workType "article" @default.