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• W2086716246 abstract "The peripheral and central nervous system are harbouring herpes simplex virus type 1 (HSV-1) and this virus has been proposed to be implicated in the aetiology of Alzheimer's disease (AD). We tested whether the HSV-1 genome is found indeed in the brain of controls, patients with AD and Down syndrome (DS) and whether HSV-1 infectious proteins in brain were induced. Moreover, we tested whether interleukin (IL)-6, a marker for neuroinflammation, is found in brains of AD and DS. HSV-1 glycoprotein D gene, as well as viral phosphoprotein and glycoprotein were detected in all brain samples. IL-6 was detectable in seven out of the eight AD and all of the eight DS patients, but only three out of ten controls in the frontal cortex. IL-6 in cerebellum was detectable in all AD and DS patients, but only three out of nine controls. In conclusion, we propose that the detection of HSV-1 genome and HSV-1 inducible protein IL-6 not only shows the presence in human brain, but may indicate a role for HSV-1 in the process of neuroinflammation and apoptosis, known to occur in both neurodegenerative disorders, AD and DS." @default.
• W2086716246 created "2016-06-24" @default.
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• W2086716246 date "2001-02-01" @default.
• W2086716246 modified "2023-09-26" @default.
• W2086716246 title "Evidence for the relation of herpes simplex virus type 1 to Down syndrome and Alzheimer's disease" @default.
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• W2086716246 doi "https://doi.org/10.1002/1522-2683(200102)22:3<445::aid-elps445>3.0.co;2-8" @default.
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